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Inhibition of sclerostin in human embryonic cells assessed as restoration of Wnt signaling by luciferase reporter gene assay
Assay data:5 Active, 6 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of biotin-labeled rat recombinant sclerostin assessed as reduction in sclerostin interaction with LRP-6/Fc incubated overnight by chemiluminescence based Alpha-screen assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of biotin-labeled human recombinant sclerostin assessed as reduction in sclerostin interaction with LRP-6/Fc incubated overnight by chemiluminescence based Alpha-screen assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human sclerostin in MC3T3E1/TetON-Wnt1/STF-Luc#5 cells assessed as sclerostin neutralizing activity by Wnt1-induced TCF/LEF luciferase reporter gene assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
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