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Inhibition of human germ cell alkaline phosphatase
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to ALP (unknown origin) assessed as Kcat/Km
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to ALP (unknown origin) assessed as catalytic constant
Binding affinity to ALP (unknown origin)
Binding affinity to human PLAP incubated for 15 mins by Fluorescence polarization assay
Assay data:14 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human PLAP using biotinylated CDP as substrate incubated for 30 mins by chemiluminescent assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PLAP (unknown origin)
Assay data:1 Active, 1 Tested
Alkaline Phosphatase Inhibition Assay from Article 10.1111/cbdd.12861: "Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase."
Assay data:10 Active, 3 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Alkaline Phosphatase Assay from Article 10.1016/j.bioorg.2017.01.003: "Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors."
Assay data:10 Active, 8 Activity ≤ 1 µM, 12 Tested
Alkaline Phosphatase Inhibition Assay from Article 10.1016/j.bioorg.2017.01.008: "Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors."
Assay data:14 Active, 12 Activity ≤ 1 µM, 16 Tested
Alkaline Phosphatase Assay from US Patent US10314827: "Methods of use of cyclopamine analogs"
Assay data:16 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Prodrug activation in human hepatocytes assessed as BMS-626529 formation
Assay data:1 Tested
Prodrug activation assessed as human placental alkaline phosphatase mediated BMS-626529 formation
Inhibition of calf intestinal alkaline phosphatase using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins
Assay data:2 Active, 2 Tested
Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as enzyme-substrate-inhibitor dissociation constant using varying levels of p-NPP as substrate by Lineweaver-Burk plot analysis
Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as enzyme-inhibitor dissociation constant using varying levels of p-NPP as substrate by Lineweaver-Burk plot analysis
Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as substrate Km at 0.3 uM using varying levels of p-NPP as substrate by Lineweaver-Burk plot analysis (Rvb = 0.833 mM)
Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as substrate Km at 0.015 uM using varying levels of p-NPP as substrate by Lineweaver-Burk plot analysis (Rvb = 0.833 mM)
Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as substrate Vmax at 0.3 uM using varying levels of p-NPP as substrate measured every minute for 10 mins by Lineweaver-Burk plot analysis (Rvb = 1.2 10'-5deltaA/s)
Inhibition of calf intestinal alkaline phosphatase using p-NPP as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins by spectrophotometric analysis
Assay data:11 Active, 4 Activity ≤ 1 µM, 11 Tested
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