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Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 250 kDa NPC1 protein expression at 50 nM pretreated for 48 hrs followed by endoglycosidase H addition and measured after overnight incubation by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 120 kDa NPC1 protein expression at 50 nM pretreated for 48 hrs followed by PNGaseF addition and measured after overnight incubation by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 120 kDa NPC1 protein expression at 50 nM measured after 48 hrs by Western blot analysis
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 180 kDa NPC1 protein expression at 50 nM pretreated for 48 hrs followed by PNGaseF addition and measured after overnight incubation by Western blot analysis
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 180 kDa NPC1 protein expression at 50 nM pretreated for 48 hrs followed by endoglycosidase H addition and measured after overnight incubation by Western blot analysis
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 100 kDa NPC1 protein expression at 50 nM pretreated for 48 hrs followed by endoglycosidase H addition and measured after overnight incubation by Western blot analysis relative to control
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 100 kDa NPC1 protein expression at 50 nM measured after 48 hrs by Western blot analysis
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as increase in 180 kDa NPC1 protein expression at 50 nM measured after 48 hrs by Western blot analysis
Binding affinity to SAP155 in human GM18407 cells harboring NPC1 R404Q/M1142T mutant assessed as restoration of cholesterol trafficking at 0.001 to 5 uM after 48 hrs by filipin-staining based fluorescence microscopic analysis
Assay data:4 Tested
Binding affinity to SAP155 in human GM18453 cells harboring NPC1 mutant assessed as restoration of cholesterol trafficking at 50 nM after 48 hrs by filipin-staining based fluorescence microscopic analysis
Assay data:4 Active, 4 Tested
Displacement of biotinylated SSA from SF3b SAP155/SAP145/SAP130 complex in human HeLa cells by competition binding assay
Displacement of Ac-SSA from SF3b SAP155/SAP145/SAP130 complex in human HeLa cells by competition binding assay
Assay data:2 Active, 2 Tested
Binding affinity to SF3b SAP155/SAP145/SAP130 complex in human HeLa cells at 2 uM by Western blotting
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