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Inhibition of recombinant GST-tagged human CENP-E assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP addition measured after 20 mins by ADPglo assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Binding affinity to recombinant human CENPE at 10 uM after 30 mins by spectrophotometric analysis relative to control
Assay data:1 Tested
Inhibition of microtubule-stimulated ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assay
Inhibition of basal ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assay
Binding affinity to human CENP-E at 10 uM
Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged CENP-E ATPase activity at 1 mM by microplate reader in presence of Mg2+ ATP relative to control
Inhibition of porcine brain microtubule-stimulated human recombinant GST-tagged CENP-E ATPase activity at 15 uM by microplate reader in presence of Mg2+ ATP relative to control
Assay data:6 Tested
Inhibition of microtubule-stimulated CENP-E motor domain (1 to 339) (unknown origin) ATPase activity at 6.3 uM
Assay data:2 Tested
Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assay
Assay data:14 Active, 9 Activity ≤ 1 µM, 14 Tested
Inhibition of ATPase activity of CENP-E motor domain (unknown origin) by high throughput screening assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CENP-E (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 1 uM after 10 to 20 mins by spectrophotometric analysis
Assay data:8 Tested
Inhibition of CENP-E (unknown origin)-mediated ATP hydrolysis assessed as residual activity at 10 uM after 10 to 20 mins by spectrophotometric analysis
Inhibition of MT-stimulated CENP-E ATPase activity
Inhibition of CENP-E ATPase activity
Inhibition of CENP-E
Inhibition of CENP-E ATPase activity at 20 uM
Inhibition of CENPE at 10 uM by puruvate kinsase-lactate dehydrogenase detection system
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