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Agonist activity at human CysLT2 receptor
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human CysLT2 receptor
Assay data:1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (CYSLTR2)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Human Whole Blood Cys LT a-IgE
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human CYSLt2 receptor at 10 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]LTD4 from human full-length recombinant cysteinyl leukotriene type-2 receptor expressed in HEK293 cells at 10 uM measured after 60 mins by scintillation counting method relative to control
Assay data:2 Tested
Activity at human CysLT2 receptor up to 10 uM
Inhibition of CysLT2 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Rat CysLT2 receptor (Leukotriene receptors)
Human CysLT2 receptor (Leukotriene receptors)
Assay data:14 Active, 14 Tested
Antagonist activity against CysLT2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pre-incubated for 10 mins before LTD4 addition by Fluo-4 AM dye based fluorimetric assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 31 Tested
Antagonist activity at CysLT2 receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM
Agonist activity at CysLT2 receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM
Antagonist activity at human CysLT2 expressed in HEK293T cells assessed as inhibition of LTC4-induced effect preincubated for 30 mins prior to LTC4 addition by Aequorin luminescence assay
Assay data:2 Active, 3 Tested
Antagonist activity at guinea pig CysLT2 expressed in CHOK1 cells assessed as inhibition of LTC4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Antagonist activity at human CysLT2 expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay
Assay data:36 Active, 3 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Assay data:15 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 15 Tested
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated at 10 uM for 30 mins before LTD4 addition by Fura2-AM assay
Assay data:21 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 21 Tested
Binding affinity to cysLTR2 (unknown origin) at 10 uM
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