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Inhibition of SPOP/PTEN interaction in human HEK293T cells assessed as reduction in PTEN level incubated for 8 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SPOP/PTEN interaction in human HEK293T cells assessed as reduction in SPOP level incubated for 20 mins by co-immunoprecipitation based Western blot analysis
Inhibition of SPOP/PTEN interaction in human OS-RC2 cells assessed as increase in SPOP level at 1 to 50 uM incubated for 20 mins by DARTS based Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SPOP/PTEN interaction in human A498 cells assessed as increase in SPOP level at 1 to 50 uM incubated for 20 mins by DARTS based Western blot analysis
Inhibition of human PTEN (1 to 403 residues) expressed in Escherichia coli strain BL21(DE3) using DiFMUP as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by fluorescence assay
Activity at human MMAC1 up to 10 uM
Human phosphatase and tensin homolog (Lipid phosphate phosphatases)
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
Assay data:2 Active, 2 Tested
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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