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Enzymatic Inhibitory Activity (IC50) Assay from US Patent US20240132517: "MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of c-MET (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of c-Met (unknown origin) phosphorylation using Tyr2 peptide as substrate in presence of ATP incubated for 1 hrs by Z-LYTE assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of His6-tagged recombinant human c-Met (974 to end residues) using 5FAM-KKK-SPGEYVNIGFG-NH2 as substrate in presence of ATP incubated for 60 mins by AiphaQuest assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of His6-tagged recombinant human c-Met using 5FAM-KKK-SPGEYVNIGFG-NH2 as substrate in presence of ATP incubated for 60 mins by AiphaQuest assay
Inhibition of c-Met (unknown origin) kinase activity using peptide as substrate in presence of 33P-ATP incubated for 20 to 30 mins by scintillation counter analysis
Inhibition of human c-Met using poly tyrosine as substrate preincubated for 5 mins followed by substrate addition in presence of ATP and measured after 30 mins by colorimetric ELISA assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of c-Met (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP by TR-FRET assay
Inhibition of c-Met (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 30 mins by HTRF assay
Inhibition of c-Met (unknown origin) kinase activity using peptide as substrate in presence of ATP incubated for 1 hrs by ELISA
Inhibition of c-Met (unknown origin) kinase activity using biotinylated poly-tyrosine as substrate in presence of ATP incubated for 1 hr by AlphaQuest analysis
Inhibition of c-Met (unknown origin)
Inhibition of recombinant c-Met (unknown origin) using poly Tyrosine peptide as substrate in presence of ATP incubated for 90 mins by Z-LYTE assay
Inhibition of recombinant c-Met (unknown origin) using peptide as substrate in presence of ATP by TR-FRET assay
Inhibition of c-Met (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISA
Assay data:12 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 12 Tested
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) at 4:1 ratio as substrate incubated for 60 mins by ELISA
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Assay data:2 Tested
Inhibition of MET (unknown origin) at 1 uM relative to control
Inhibition of human recombinant GST-fused c-MET expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:2 Active, 2 Tested
Inhibition of c-Met (unknown origin) incubated for 1 hrs in presence of ATP by ELISA assay
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