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Binding affinity to HIF-2alpha/ARNT (unknown origin) assessed as change in melting temperature at 10 uM by protein thermal shift assay
Assay data:34 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human ARNT (85 to 465 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as increase in melting temperature at 200 uM measured after 30 mins by differential scanning fluorimetry analysis
Assay data:1 Tested
Binding affinity to human ARNT (85 to 465 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as increase in melting temperature at 10 uM measured after 10 mins by differential scanning fluorimetry analysis
Inhibition of HIF1beta in HEK293T cells under hypoxic condition at 1 uM after 24 hrs by Western blot analysis
Assay data:3 Tested
Inhibition of HIF-1 beta in human MDA-MB-231 cells at 1 to 20 uM by Western blotting analysis
Inhibition of HIF-1 beta in human PC3 cells after 18 hrs by Western blotting analysis in hypoxia condition
Inhibition of GST-tagged PAS-B domain of HIF-2alpha-Flag-tagged PAS-B domain of ARNT heterodimerization (unknown origin) by luminescence proximity assay
Assay data:15 Active, 11 Activity ≤ 1 µM, 43 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of hypoxia-induced nuclear HIF1beta in human T47D cells at 10 uM after 4 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of hypoxia-induced HIF1beta activation in human T47D cells at 0.3 uM after 4 hrs by Western blotting
Assay data:5 Tested
Inhibition of hypoxia-induced HIF1beta activation in human T47D cells at 10 uM after 4 hrs by Western blotting
Inhibition of hypoxia-induced HIF1beta protein accumulation in human AGS cells after 12 hrs by Western blot
Assay data:2 Tested
Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by Western blot analysis in presence of ascorbate
Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by Western blot analysis in presence of 150 uM iron(3)
Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by Western blot analysis in presence of 300 uM iron(2)
Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by Western blot analysis
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