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Inhibition of Leishmania major PTR1 at 5 uM
Assay data:29 Tested
SummaryPubMed CitationRelated BioAssays by Target
Lipophilicity, log D of the compound in octanol buffer at pH 7.4
Assay data:25 Tested
SummaryPubMed Citation
Solubility of the compound at pH 7.4
Antileishmanial activity against Leishmania major MHOM/SU/73/5-ASKH assessed as growth by Alamar blue assay
Assay data:1 Tested
Antileishmanial activity against Leishmania mexicana MHOM/BZ/84/BEL46 assessed as growth by Alamar blue assay
Assay data:2 Tested
Cytotoxicity against human MRC5 cells at 100 ug/ml after 72 hrs by Alamar blue assay
Assay data:6 Tested
Cytotoxicity against human MRC5 cells after 72 hrs by Alamar blue assay
Antileishmanial activity against Leishmania major MHOM/SU/73/5-ASKH assessed as growth at 50 ug/ml by Alamar blue assay in presence of pyrimethamine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine DHFR inhibitor
Antileishmanial activity against Leishmania major MHOM/SU/73/5-ASKH assessed as growth at 50 ug/ml by Alamar blue assay
Assay data:7 Tested
Antileishmanial activity against Leishmania mexicana MHOM/BZ/84/BEL46 assessed as growth at 50 ug/ml by Alamar blue assay in presence of pyrimethamine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine DHFR inhibitor
Antileishmanial activity against Leishmania mexicana MHOM/BZ/84/BEL46 assessed as growth at 50 ug/ml by Alamar blue assay
Inhibition of Leishmania major PTR1 at 500 uM
Assay data:47 Tested
Inhibition of human DHFR at 25 uM
Inhibition of human DHFR at 100 uM
Inhibition of human DHFR at 50 uM
Inhibition of human DHFR at 1 mM
Inhibition of human DHFR at 500 uM
Assay data:9 Tested
Inhibition of human DHFR
Assay data:4 Tested
Inhibition of Leishmania major DHFR at 1 mM
Inhibition of Leishmania major DHFR at 25 uM
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