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WT-6x from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
WT-3x from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
HCT116-D130V 3x biary selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
HCT116-D130V IC95 biaryl selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
HCT116-D130V IC50 biaryl selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Assay data:3 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
HCT116-D130V not selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Wild-type 3x biaryl selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Wild-type IC95 biaryl selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Wild-type IC50 biaryl selected from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
Wild-type HCT116 from Article 10.1038/nchembio.2007.34: "ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism."
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