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Determination of FXIIa Inhibition from US Patent US20240059691: "ENZYME INHIBITORS"
Assay data:275 Active, 166 Activity ≤ 1 µM, 340 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of TRKC (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of tubulin polymerization (unknown origin) by fluorescence assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of tubulin polymerization (unknown origin) incubated for 15 mins followed by GTP addition and measured for 20 mins by spectrophotometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ALOX5 (unknown origin) assessed as reduction in calmodulin level
Assay data:3 Tested
Inhibition of ALOX5 (unknown origin) assessed as reduction in 5-HETE formation
Assay data:1 Tested
Inhibition of ALOX5 (unknown origin) at 0.00000001 M relative to control
Inhibition of ALOX5 (unknown origin) at 0.0000001 M relative to control
Inhibition of ALOX5 (unknown origin) at 0.000001 M relative to control
Assay data:8 Tested
Inhibition of ALOX5 (unknown origin) at 0.00001 M relative to control
Inhibition of TRKC (unknown origin) at 1 uM relative to control
Induction of microtubule stabilization in human HeLa cells assessed as effect on cellular cytoskeletal network of tubulin at 5 to 10 uM incubated for 4 hrs by Alexa Fluor 488 staining based confocal microscopic analysis
Assay data:2 Active, 2 Tested
Induction of microtubule stabilization (unknown origin) at 1 to 5 uM
Induction of microtubule stabilization (unknown origin) at 0.2 to 5 uM
Induction of microtubule destabilization (unknown origin) at 5 uM
Induction of microtubule stabilization (unknown origin) at 5 uM
Inhibition of 5-LOX in human PMNL at 10 uM relative to control
Assay data:23 Tested
Inhibition of 5-LOX (unknown origin)
Assay data:29 Active, 7 Activity ≤ 1 µM, 29 Tested
Inhibition of tubulin polymerization in human HCT-116 cells
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