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Inhibitory Effect of Compounds on the Replication of Novel Coronavirus from US Patent US20240140975: "ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG"
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Enzymatic Inhibitory Activity (IC50) Assay from US Patent US20240132517: "MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Inhibitory Activity Assay from US Patent US20240132489: "AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:55 Active, 55 Activity ≤ 1 µM, 55 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary
Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay: Summary
Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested
Activity Inhibition Assay on CDK Family Kinases from US Patent US20240109898: "SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF"
Assay data:84 Active, 83 Activity ≤ 1 µM, 84 Tested
Kinase Assay from US Patent US20240109865: "INDAZOLE COMPOUNDS AS KINASE INHIBITORS"
Assay data:359 Active, 363 Activity ≤ 1 µM, 363 Tested
CDK6/Cyclin D3 ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:67 Active, 67 Activity ≤ 1 µM, 67 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
CDK4/Cyclin D1 (Chelation-Enhance Fluorescence)(CHEF) Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:116 Active, 99 Activity ≤ 1 µM, 122 Tested
CDK4/Cyclin D1 Mobility Shift Assay (MSA) from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:55 Active, 49 Activity ≤ 1 µM, 55 Tested
CDK2/Cyclin E1 Full Length ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:111 Active, 104 Activity ≤ 1 µM, 122 Tested
Inhibition of Proteolytic Activity Asay from US Patent US20240092759: "Non-Covalent Inhibitors of the Main Protease of SARS-CoV-2 and Methods of Use"
Assay data:33 Active, 29 Activity ≤ 1 µM, 40 Tested
Enzymatic Assay from US Patent US20240083885: "COMPOSITIONS AND METHODS FOR INHIBITING M PRO PROTEASE ACTIVITY AND FOR PREVENTING AND TREATING SARS-COV-2 INFECTION"
Assay data:33 Active, 6 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
PI3K-gamma Scintillation Proximity Assay from US Patent US11926616: "Aminopyrazine diol compounds as PI3K-γ inhibitors"
Assay data:46 Active, 46 Activity ≤ 1 µM, 46 Tested
CDK2/Cyclin E1 HTRF Enzyme Activity Assay from US Patent US11919904: "Sulfonylamide compounds as CDK2 inhibitors"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
SARS-CoV-2 3C-like (3CL) protease fluorescence assay (FRET) from US Patent US11912714: "Spiropyrrolidine derived antiviral agents"
Assay data:47 Active, 48 Activity ≤ 1 µM, 48 Tested
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