BioAssay by Target (List) for Gene (Select 9448) - PubChem BioAssay - NCBI

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Select item 11641161.

Inhibition of human recombinant MAP4K4 using Ulight-FLGFTYVAP substrate assessed as remaining enzyme activity at 1 uM after 90 mins relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1164116

Summary PubMed Citation Related BioAssays by Target

Select item 11388122.

Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:19 Active, 16 Activity ≤ 1 µM, 19 Tested

AID:: 1138812

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 11426193.

Inhibition of MAP4K4 (unknown origin) assessed as residual activity at 0.01 uM by radioisotopic assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1142619

Summary PubMed Citation Related BioAssays by Target

Select item 11426204.

Inhibition of MAP4K4 (unknown origin) assessed as residual activity at 0.1 uM by radioisotopic assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1142620

Summary PubMed Citation Related BioAssays by Target

Select item 11426215.

Inhibition of MAP4K4 (unknown origin) assessed as residual activity at 1 uM by radioisotopic assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1142621

Summary PubMed Citation Related BioAssays by Target

Select item 11426226.

Inhibition of MAP4K4 (unknown origin) assessed as residual activity at 10 uM by radioisotopic assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1142622

Summary PubMed Citation Related BioAssays by Target

Select item 11430177.

Inhibition of MAP4K4 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:3 Tested

AID:: 1143017

Summary PubMed Citation Related BioAssays by Target

Select item 11595068.

Identification of proteins required for the processing of the EWS-FLI1 nascent transcript

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59220 Tested

AID:: 1159506

Select item 11595789.

A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:1034 Active, 18120 Tested

AID:: 1159578

Summary Related BioAssays by Depositor

Select item 115958410.

A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:2442 Active, 18052 Tested

AID:: 1159584

Summary PubMed Citation

Select item 113881111.

Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon resonance analysis

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Active, 8 Tested

AID:: 1138811

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 117084212.

Inhibition of MAP4K4 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:3 Tested

AID:: 1170842

Summary PubMed Citation Related BioAssays by Target

Select item 117312113.

Inhibition of MAP4K4 (unknown origin) at 0.1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1173121

Summary PubMed Citation Related BioAssays by Target

Select item 117318714.

Inhibition of MAP4K4 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1173187

Summary PubMed Citation Related BioAssays by Target

Select item 117723415.

Inhibition of MAP4K4 (unknown origin) in presence of 1 mM ATP

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1177234

Summary PubMed Citation Related BioAssays by Target

Select item 118851716.

Binding affinity to MAP4K4 (unknown origin) by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Active, 8 Tested

AID:: 1188517

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 118851817.

Inhibition of human MAP4K4 using LGRDKYKTLRQIRQ-COOH peptide substrate by LC3K assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:31 Active, 15 Activity ≤ 1 µM, 35 Tested

AID:: 1188518

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 118852718.

Inhibition of MAP4K4 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:2 Tested

AID:: 1188527

Summary PubMed Citation Related BioAssays by Target

Select item 118980819.

Inhibition of MAP4K4 (unknown origin) at 5.5 uM by Caliper Mobility Shift Assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:5 Tested

AID:: 1189808

Summary PubMed Citation Related BioAssays by Target

Select item 119098320.

Inhibition of HGK (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase kinase 4

Assay data:1 Tested

AID:: 1190983

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (64)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (45)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (63)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (261)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (229)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (73)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 9448) (305)
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Genes with a similar H3K4me3 profile for Gene (Select 9448) (53)
Gene
CNE-3 [Homo sapiens]
CNE-3 [Homo sapiens]
Gene ID:108353831

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