Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Antagonist activity at GPR55 (unknown origin) by beta-arrestin recruitment assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human GPR55 expressed in HEK293 cells coexpressing serum response element assessed as inhibition of LPI-induced MAPK/ERK signalling pathway by measuring SRE response incubated for 5 hrs in serum-free medium by luciferin based bioluminescence analysis
Assay data:2 Active, 2 Tested
Inverse agonist activity at human GPR55 expressed in HEK293 cells coexpressing serum response element assessed as reduction in MAPK/ERK signalling pathway by measuring SRE response incubated for 5 hrs in serum-free medium by luciferin based bioluminescence analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human GPR55 expressed in human U2OS cells assessed as inhibition of LPI-induced receptor activation by measuring beta-arrestin 2 recruitment preincubated for 30 mins followed by LPI addition and measured after 75 mins by microplate reader analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at beta-galactosidase fused human GPR55 expressed in CHO cells assessed as inhibition of LPI-induced receptor activation by measuring beta-arrestin 2 recruitment at upto 10 uM incubated for 90 mins by PathHunter chemiluminescence based assay
Assay data:11 Tested
Antagonist activity at beta-galactosidase fused human GPR55 expressed in CHO cells assessed as inhibition of LPI-induced receptor activation by measuring beta-arrestin 2 recruitment incubated for 90 mins by PathHunter chemiluminescence based assay
Assay data:11 Active, 2 Activity ≤ 1 µM, 13 Tested
Binding affinity to GPR55 (unknown origin) assessed as reduction in LPI-mediated ERK1/2 activation relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human GPR55 expressed in HEK293 cells assessed as LPI-stimulated ERK1/2 phosphorylation by measuring efficacy relative to control
Binding affinity to human GPR55 expressed in HEK293 cells assessed as LPI-stimulated ERK1/2 phosphorylation
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at GPR55 (unknown origin) expressed in HEK293 cells assessed as LPI-stimulated ERK1/2 phosphorylation by measuring efficacy relative to control
Antagonist activity at GPR55 (unknown origin) expressed in HEK293 cells assessed as LPI-stimulated ERK1/2 phosphorylation
PRESTO-Tango GPCRome screening (GPR55)
Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta arrestin recruitment at 10 uM after 90 mins by beta-galactosidase based topcount luminescence analysis relative to control
Assay data:18 Tested
Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis
Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase based topcount luminescence analysis relative to control
Assay data:19 Tested
Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis
Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintillation counting method
Allosteric modulation of human PK-tagged Gq-coupled GPR55 expressed in CHOK1 cells assessed as induction of L-alpha-Lysophosphatidylinositol-mediated beta-arrestin recruitment by pathhunter assay
Assay data:2 Tested
Inverse agonist activity at GPR55 in human T47D cells assessed as reduction in cell viability at 5 uM treated 30 mins after 10 uM GPR55 selective antagonist CID16020046 treatment followed by incubation for 24 hrs by MTT assay
Inverse agonist activity at GPR55 in human MCF7 cells assessed as reduction in cell viability at 5 uM treated 30 mins after 10 uM GPR55 selective antagonist CID16020046 treatment followed by incubation for 24 hrs by MTT assay
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on