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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
Inhibition of GFP-tagged human p115 RhoGEF DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in human full length RhoA (1 to 193 residues) interaction with p115 RhoGEF at 30 to 50 uM incubated for 1 hr by Western blot analysis based GST-RhoA pull-down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of p115 DHPH22 domain (395 to 766 residues) (unknown origin) interaction with GDP-loaded His-tagged RhoA F25N mutant (1 to 180 residues) assessed as reduction in BODIPY-GTP-GDP exchange at 200 uM pretreated for 30 mins followed by RhoA addition by fluorescence based spectrophotometric method relative to control
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of p115 DHPH22 domain (395 to 766 residues) (unknown origin) interaction with GDP-loaded His-tagged RhoA F25N mutant (1 to 180 residues) assessed as reduction in BODIPY-GTP-GDP exchange pretreated for 30 mins followed by RhoA addition by fluorescence based spectrophotometric method
Assay data:1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 15 uM in presence of 15 uM Rhosin/G04 pull-down assay (Rvb = 1 No unit)
SummaryRelated BioAssays by Target
Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 5 uM in presence of 5 uM Rhosin/G04 pull-down assay (Rvb = 1 No unit)
Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 2.5 uM in presence of 2.5 uM Rhosin/G04 pull-down assay (Rvb = 1 No unit)
Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 50 uM pull-down assay (Rvb = 1 No unit)
Assay data:2 Tested
Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 30 uM pull-down assay (Rvb = 1 No unit)
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