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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity towards human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:101 Active, 19 Activity ≤ 1 µM, 846 Tested
Antagonist activity at human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:15 Active, 10 Activity ≤ 1 µM, 522 Tested
Agonist activity at human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:41 Active, 11 Activity ≤ 1 µM, 580 Tested
Inhibition of PXR (unknown origin) upto 10000 nM
Activation of human PXR expressed in human DPX2 co-expressing luciferase reporter gene assessed as fold increase incubated for 24 hrs by luciferase assay relative to control
Assay data:4 Tested
Activation of human PXR expressed in human DPX2 co-expressing luciferase reporter gene assessed as maximum efficacy incubated for 24 hrs by luciferase assay relative to control
Activation of human PXR expressed in human DPX2 co-expressing luciferase reporter gene incubated for 24 hrs by luciferase assay
Transactivation of PXR (unknown origin) relative to control
Assay data:10 Tested
Transactivation of PXR (unknown origin)
Assay data:8 Active, 1 Activity ≤ 1 µM, 14 Tested
Activation of human PXR
Inhibition of PXR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Activation of PXR (unknown origin) in human DPX2 cells assessed as maximal efficacy at 15 uM relative to control
Assay data:2 Tested
Activation of PXR (unknown origin) relative to control
Assay data:12 Tested
Activation of PXR (unknown origin) at 10 uM relative to control
Assay data:3 Tested
Activation of PXR (unknown origin)
Assay data:6 Active, 3 Activity ≤ 1 µM, 12 Tested
Activation of PXR in human HepG2 cells at 10 uM incubated for 48 hrs relative to rifampicin
Activation of PXR in human HepG2 cells at 1 uM incubated for 48 hrs relative to rifampicin
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