BioAssay by Target (List) for Gene (Select 8658) - PubChem BioAssay - NCBI

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Select item 19428621.

Inhibition of TNKS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1942862

Summary Related BioAssays by Target

Select item 19428592.

Inhibition of human recombinant TNKS1

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1942859

Summary Related BioAssays by Target

Select item 19428583.

Inhibition of human recombinant full length TNKS1 (1030 to 1317 residues) expressed in Escherichia coli assessed as inhibition by fluorescence based analysis

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1942858

Summary Related BioAssays by Target

Select item 19252764.

Inhibition of tankyrase-mediated auto-PARsylation in human DLD-1 cells assessed as increase in tankyrase accumulation incubated for 24 hrs

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Tested

AID:: 1925276

Summary Related BioAssays by Target

Select item 19252035.

Inhibition of TNKS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1925203

Summary Related BioAssays by Target

Select item 19252026.

Binding affinity to recombinant human TNKS1 (1091 to 1327 residues) assessed as dissociation constant by ITC method

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1925202

Summary Related BioAssays by Target

Select item 19251887.

Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:23 Active, 4 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 24 Tested

AID:: 1925188

Summary Related BioAssays by Target

Select item 19251878.

Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 90 mins by TR-FRET analysis

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Tested

AID:: 1925187

Summary Related BioAssays by Target

Select item 19242779.

Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate at 3 uM incubated for 1 hr by ELISA relative to control

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Tested

AID:: 1924277

Summary Related BioAssays by Target

Select item 192425810.

Inhibition of human TNKS1 (1030 to 1317 residues) measured after 20 hrs

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1924258

Summary Related BioAssays by Target

Select item 192425311.

Inhibition of TNKS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1924253

Summary Related BioAssays by Target

Select item 192425012.

Binding affinity to TNKS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1924250

Summary Related BioAssays by Target

Select item 192377213.

Inhibition of TNKS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1923772

Summary Related BioAssays by Target

Select item 189578114.

Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constant

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 1895781

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189576915.

Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assay

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Active, 6 Tested

AID:: 1895769

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 188234216.

Inhibition of human recombinant TNKS1/TNKS2 (unknown origin) by chemiluminescent assay

Source:: ChEMBL

Protein Targets:: Poly [ADP-ribose] polymerase tankyrase-1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1882342

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187225717.

Inhibition of tankyrase 1 (unknown origin) incubated for 1 hr by chemiluminescence assay

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1872257

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186918218.

Inhibition of TNKS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:4 Tested

AID:: 1869182

Summary PubMed Citation Related BioAssays by Target

Select item 186916819.

Inhibition of N-terminal his-tagged human TNKS1 expressed in Escherichia coli Rosette2 (DE3)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:2 Tested

AID:: 1869168

Summary PubMed Citation Related BioAssays by Target

Select item 186916320.

Inhibition of TNKS1 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)

Source:: ChEMBL

Protein Target:: Poly [ADP-ribose] polymerase tankyrase-1

Assay data:1 Tested

AID:: 1869163

Summary PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (131)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (14)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (105)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (133)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (193)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (193)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (12)
BioAssays deposited by other experimentalists

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