BioAssay by Target (List) for Gene (Select 8622) - PubChem BioAssay - NCBI

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Select item 19244641.

Inhibition of PDE8B (unknown origin)

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1924464

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19235752.

Inhibition of PDE8B (unknown origin)

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1923575

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18725853.

Inhibition of PDE8B (unknown origin)

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1872585

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18592684.

Inhibition of cAMP-specific 3',5'-cyclic phosphodiesterase (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1859268

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18137415.

Inhibition of human PDE4 at 10 uM relative to control

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1813741

Summary PubMed Citation Related BioAssays by Target

Select item 18121196.

Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1812119

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16864177.

Inhibition of PDE8B (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Tested

AID:: 1686417

Summary PubMed Citation Related BioAssays by Target

Select item 16853578.

Inhibition of PDE (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1685357

Summary PubMed Citation Related BioAssays by Target

Select item 16369939.

Inhibition of human PDE

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Active, 1 Tested

AID:: 1636993

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 150858810.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 149573811.

Inhibition of full length recombinant human PDE8B using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assay

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1495738

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 127922312.

Inhibition of full length human recombinant PDE8B using [3H]-cAMP as substrate by scintillation proximity assay

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Active, 1 Tested

AID:: 1279223

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 123790013.

Inhibition of human PDE8B

Source:: ChEMBL

Protein Target:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Assay data:1 Active, 1 Tested

AID:: 1237900

Summary Compounds, Active Related BioAssays by Target

Select item 122483014.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:2853 Active, 18113 Tested

AID:: 1224830

Summary Related BioAssays by Same Project

Select item 118557315.

Inhibition of PDE8 (unknown origin)

Source:: ChEMBL

Protein Targets:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; ...
Total:: 2

Assay data:1 Tested

AID:: 1185573

Summary PubMed Citation Related BioAssays by Target

Select item 118189116.

Inhibition of PDE8 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Targets:: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; ...
Total:: 2

Assay data:2 Tested

AID:: 1181891

Summary PubMed Citation Related BioAssays by Target

Select item 115958417.

A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:2442 Active, 18052 Tested

AID:: 1159584

Summary PubMed Citation

Select item 115957818.

A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:1034 Active, 18120 Tested

AID:: 1159578

Summary Related BioAssays by Depositor

Select item 115950619.

Identification of proteins required for the processing of the EWS-FLI1 nascent transcript

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59220 Tested

AID:: 1159506

Select item 111735720.

InfectX: Pathogen infection siRNA screens

Source:: InfectX Consortium

Assay data:115372 Tested

AID:: 1117357

Summary PubMed Citation

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (12)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (11)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (28)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (32)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (32)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (12)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 8622) (45)
PubChem BioAssay
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase ...
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7 [Homo sapiens]
gi|1167803576|ref|NP_001336678.1|

Protein
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase ...
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11 [Homo sapiens]
gi|2372013708|ref|NP_001401551.1|

Protein
Homo sapiens phosphodiesterase 8B (PDE8B), transcript variant 17, mRNA
Homo sapiens phosphodiesterase 8B (PDE8B), transcript variant 17, mRNA
gi|1774222043|ref|NM_001376067.1|

Nucleotide
Clostridium symbiosum CE91-St66
Clostridium symbiosum CE91-St66

biosample

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