BioAssay by Target (List) for Gene (Select 84451) - PubChem BioAssay - NCBI

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Select item 18646181.

Inhibition of human MLK4 at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1864618

Summary PubMed Citation Related BioAssays by Target

Select item 18350512.

MLK4(h) Kinase panel

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1835051

Summary Related BioAssays by Target

Select item 18342233.

Inhibition of MLK4 (unknown origin)at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1834223

Summary PubMed Citation Related BioAssays by Target

Select item 17874044.

MLK4(h) Millipore kinase panel

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1787404

Summary Related BioAssays by Target

Select item 17862575.

MLK4 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1786257

Summary Related BioAssays by Target

Select item 17494816.

Inhibition of MLK4 (unknown origin) assessed as residual activity measured at 1 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:3 Tested

AID:: 1749481

Summary Related BioAssays by Target

Select item 17463267.

Inhibition of MLK4 in human NCI-H929 cells at 10 uM by mass spectroscopic analysis relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:3 Tested

AID:: 1746326

Summary Related BioAssays by Target

Select item 17463258.

Inhibition of MLK4 in human NCI-H929 cells by mass spectroscopic analysis

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:3 Tested

AID:: 1746325

Summary Related BioAssays by Target

Select item 17156139.

Inhibition of human MLK4 assessed as residual activity using MEK1 as substrate at 1 uM by [gamma-33P]-ATP assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1715613

Summary PubMed Citation Related BioAssays by Target

Select item 171526310.

Inhibition of human MLK4 using MEK1 as substrate by [gamma-33P]-ATP assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1715263

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 167964611.

Inhibition of human MLK4 using MEK1 as substrate assessed as residual activity at 1 uM by [gamma-33P]-ATP assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:2 Tested

AID:: 1679646

Summary PubMed Citation Related BioAssays by Target

Select item 160627212.

Inhibition of MLK4 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1606272

Summary PubMed Citation Related BioAssays by Target

Select item 156855113.

Inhibition of human MLK4 at 100 nM using MEK1 as substrate by [gamma-33P]-ATP assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1568551

Summary PubMed Citation Related BioAssays by Target

Select item 153817714.

Inhibition of recombinant human MLK4 assessed as residual activity at 1 uM using by radiometry assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1538177

Summary PubMed Citation Related BioAssays by Target

Select item 153178015.

Inhibition of human MLK4 using MEK1 as substrate by [gamma-33P]-ATP assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Active, 1 Tested

AID:: 1531780

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 153141616.

Inhibition of human MLK4 assessed as residual activity at 100 uM using MEK1 as substrate by [gamma-33P]-ATP assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1531416

Summary PubMed Citation Related BioAssays by Target

Select item 153105217.

Inhibition of human MLK4 assessed as residual activity at 1 uM using MEK1 as substrate by [gamma-33P]-ATP assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:2 Tested

AID:: 1531052

Summary PubMed Citation Related BioAssays by Target

Select item 150858818.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 149018319.

Inhibition of MLK4 in human SKCO1 cells at 1 uM after 4 hrs using biotin labeled DLKSSNILLLEK probe by mass-spectrometric analysis relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:3 Tested

AID:: 1490183

Summary PubMed Citation Related BioAssays by Target

Select item 147900020.

Inhibition of MLK4 Lysine 2 labelling site (unknown origin) at 10 uM

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase kinase kinase 21

Assay data:1 Tested

AID:: 1479000

Summary PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (2)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (1)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (4)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (21)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (15)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (48)
BioAssays deposited by other experimentalists

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