BioAssay by Target (List) for Gene (Select 8444) - PubChem BioAssay - NCBI

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Select item 11172811.

A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:555 Active, 64752 Tested

AID:: 1117281

Summary PubMed Citation

Select item 12239152.

Inhibition of DYRK3 (unknown origin) at 100 nM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1223915

Summary PubMed Citation Related BioAssays by Target

Select item 12053473.

Inhibition of DYRK3 (unknown origin) assessed as remaining activity at 100 uM by radioactive filter binding assay in presence of [33P]-ATP relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:16 Tested

AID:: 1205347

Summary PubMed Citation Related BioAssays by Target

Select item 12031624.

Inhibition of Dyrk3 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1203162

Summary PubMed Citation Related BioAssays by Target

Select item 11828605.

Inhibition of DYRK3 (unknown origin) assessed as residual activity at 1 uM by radiometric protein kinase assay

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1182860

Summary PubMed Citation Related BioAssays by Target

Select item 11731696.

Inhibition of DYRK3 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1173169

Summary PubMed Citation Related BioAssays by Target

Select item 11731037.

Inhibition of DYRK3 (unknown origin) at 0.1 uM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1173103

Summary PubMed Citation Related BioAssays by Target

Select item 11656158.

Inhibition of DYRK3 (unknown origin) assessed as remaining enzyme activity at 10 uM by radioactive [33P]-ATP filter binding assay

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1165615

Summary PubMed Citation Related BioAssays by Target

Select item 11630499.

Inhibition of DYRK3 (unknown origin) assessed as residual enzyme activity at 10 uM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:4 Tested

AID:: 1163049

Summary PubMed Citation Related BioAssays by Target

Select item 115958410.

A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:2442 Active, 18052 Tested

AID:: 1159584

Summary PubMed Citation

Select item 115957811.

A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:1034 Active, 18120 Tested

AID:: 1159578

Summary Related BioAssays by Depositor

Select item 115950612.

Identification of proteins required for the processing of the EWS-FLI1 nascent transcript

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59220 Tested

AID:: 1159506

Select item 115731613.

Inhibition of DYRK3 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Active, 1 Tested

AID:: 1157316

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 111735714.

InfectX: Pathogen infection siRNA screens

Source:: InfectX Consortium

Assay data:115372 Tested

AID:: 1117357

Summary PubMed Citation

Select item 122483015.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:2853 Active, 18113 Tested

AID:: 1224830

Summary Related BioAssays by Same Project

Select item 111726916.

Human kinome siRNA screen in A549-BTR and MDA-231-1833-BTR cells

Source:: Nyati Lab, University of Michigan Medical School

Assay data:49 Active, 714 Tested

AID:: 1117269

Summary PubMed Citation

Select item 106234817.

Inhibition of human DYRK3 at 5 x 10'-8 M relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 1062348

Summary PubMed Citation Related BioAssays by Target

Select item 105663118.

Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:3 Active, 3 Activity ≤ 1 µM, 6 Tested

AID:: 1056631

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 76058019.

Inhibition of Dyrk-3 (unknown origin) assessed as residual activity at 0.1 uM/L relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Tested

AID:: 760580

Summary PubMed Citation Related BioAssays by Target

Select item 76057020.

Inhibition of Dyrk-3 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 760570

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (41)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (25)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (33)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (165)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (148)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (59)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 8444) (209)
PubChem BioAssay
txid55885[Organism:exp] (517)
PopSet
homeobox protein Nkx-2.1 isoform 2 [Homo sapiens]
homeobox protein Nkx-2.1 isoform 2 [Homo sapiens]
gi|4507715|ref|NP_003308.1|

Protein
xl11019G01R_1375521 Xenopus ORFeome version 1.0 library Xenopus laevis cDNA clon...
xl11019G01R_1375521 Xenopus ORFeome version 1.0 library Xenopus laevis cDNA clone xl11019G01 3', mRNA sequence
gi|798035615|gnl|dbEST|79647561|gb| 859.1|

Nucleotide
xl11019C10F_1290391 Xenopus ORFeome version 1.0 library Xenopus laevis cDNA clon...
xl11019C10F_1290391 Xenopus ORFeome version 1.0 library Xenopus laevis cDNA clone xl11019C10 5', mRNA sequence
gi|798034920|gnl|dbEST|79642359|gb| 657.1|

Nucleotide

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