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Inhibition of Caspase Activity Assay from US Patent US11447497: "(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Caspase Catalytic Activity Assay from Article 10.1016/j.chembiol.2017.02.003: "Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:15 Active, 9 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
In Vitro Inhibitory Activity of Caspase from US Patent US10167313: "Selective caspase inhibitors and uses thereof"
Assay data:18 Active, 17 Activity ≤ 1 µM, 25 Tested
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Peptidase, CASP9 (Caspase 9) Eurofins-Panlabs enzyme assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of Caspase 9 (unknown origin) at 100 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Caspase 9 (unknown origin) at 10 uM
Assay data:3 Tested
Activation of caspase 9 in human SMMC7721 cells
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human caspase 9 expressed in Escherichia coli at 10 uM using Ac-LEHD-AFC as substrate after 60 mins by spectrophotometric analysis relative to control
Inhibition of caspase9 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
Inhibition of human full-length recombinant caspase 9 expressed in Escherichia coli at 10 uM using Ac-LEHD-AFC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by spectrofluorimetric analysis relative to control
Inhibition of N-terminal CARD domain of caspase 9 (unknown origin)
Inhibition of caspase-9 (unknown origin) at 10 uM
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Activation of caspase cascade in human T47D cells using N-(Ac-DEVD)-N'-ethoxycarbonyl-R110 fluorogenic substrate incubated for 48 hrs by fluorescent plate reader based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activation of caspase (unknown origin)
Human Caspase 9 (C14: Caspase)
Assay data:2 Active, 2 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
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