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Rat MCH1 receptor (Melanin-concentrating hormone receptors)
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to rat MCHR1
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]-MCH(4 to 19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting
Assay data:23 Active, 24 Activity ≤ 1 µM, 24 Tested
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis
Assay data:26 Active, 37 Activity ≤ 1 µM, 37 Tested
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 at 10 uM by scintillation counting analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis
Assay data:31 Active, 3 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Antagonist activity against rat MCHR1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to rat MCH-R1
Antagonist activity at rat MCHR1 assessed as 2-(4-chlorophenyl)-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one
Antagonist activity at rat MCHR1 assessed as 6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Antagonist activity at rat MCHR1
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at rat MCH1 receptor expressed in HEK 293T cells assessed as inhibition of MCH-induced Ca2+ mobilization after 10 mins by FLIPR assay
Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting
Assay data:22 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 24 Tested
Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 1 hr by scintillation counting
Antagonist activity at rat MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilization
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at rat MCHR1 expressed in HEK293 cells by aequorin bioluminescence assay
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells
Assay data:12 Active, 12 Activity ≤ 1 µM, 16 Tested
Displacement of [125I]-S36057 from rat MCH1 receptor
Antagonist activity at rat MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting
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