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Inhibition of GLP (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000196bCl EHMT1
Assay data:1 Tested
Selectivity interaction (Methyltransferase panel (radioactive enzyme assay)) EUB0000216b EHMT1
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b EHMT1
Affinity Biochemical interaction (Scintillation proximity assay (SPA)) EUB0000212b EHMT1/GLP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (Enzymatic activity assay) EUB0000194b EHMT1/GLP
Affinity Phenotypic Cellular interaction (In-Cell Western assay (H3K9Me2 antibody immunofluorescence in PC3 cells)) EUB0000212b EHMT1/GLP
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Immunofluorescence in-cell Western (reduction of H3K9me2 in MDA MB231 cells)) EUB0000194b EHMT1/GLP
Inhibition of GLP in human HepG2 cells assessed as reduction in H3K9Me2 expression at 1.25 to 20 uM measured after 24 hrs by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GLP at 10 uM by radioisotope-based filter binding assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of EHMT1 (unknown origin)
Inhibition of human GLP (982 to 1266 residues) using H3 peptide substrate preincubated for 5 mins followed by SAM addition measured after 10 mins by SAHH-coupled biochemical assay
Inhibition of human GLP (982 to 1266 residues) assessed as covalent modification by measuring GLP adduct formation by mass spectrometry
Inhibition of human GLP (982 to 1266 residues) using H3 peptide as substrate in presence of SAM cofactor by scintillation counting method
Binding affinity to human GLP (982 to 1266 residues) assessed as dissociation constant measured after 1 hr by isothermal titration calorimetry method
Binding affinity to human GLP (982 to 1266 residues) assessed as dissociation constant by isothermal titration calorimetry method
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human GLP (982 to 1266 residues) using H3 peptide as substrate measured upto 45 mins in presence of SAM cofactor
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human recombinant GLP (874 to 1298 residues) expressed in Escherichia coli at 50 uM by hotspot assay relative to control
Inhibition of human recombinant GLP (874 to 1298 residues) expressed in Escherichia coli at 10 uM by hotspot assay
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