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Binding affinity to PARP8 (unknown origin) assessed as apparent dissociation constant
Assay data:4 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PARP8 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal His-tagged full length human PARP8 expressed in Escherichia coli BL21 (DE3) at 10 uM preincubated with 6-a-NAD+ for 5 to 10 mins followed by enzyme addition and measured after 60 mins using NAD+ as substrate byHRP based chemiluminescence assay
Assay data:6 Tested
Inhibition of PARP8 (unknown origin) assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control
Assay data:2 Tested
Inhibition of PARP-8 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assay
Assay data:1 Active, 1 Tested
Inhibition of human recombinant PARP8 by chemiluminescence method
Inhibition of GFP-tagged human PARP8 expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by chemiluminescent immunoprecipitation assay
Inhibition of PARP8 (unknown origin) at 1 uM using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay relative to control
Inhibition of PARP8 (unknown origin) at 500 nM using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay relative to control
Assay data:5 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of human recombinant PARP8 at 100 uM incubated for 1 hr using using NAD+, biotinylated NAD+ and activated DNA by luminescence based assay
Inhibition of human recombinant PARP8 at 10 uM incubated for 1 hr using using NAD+, biotinylated NAD+ and activated DNA by luminescence based assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Inhibition of recombinant human PARP-8 at 10 uM relative to control
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Binding affinity to ATRD8 (unknown origin) assessed as change in melting temperature by thermal stabilization assay
Assay data:56 Tested
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