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TLR-pathway-human_R848 ligand_TNF readout
Assay data:134 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Activation of human TLR4 fransfectoma in HEK Blue cells at 0.5 uM relative to LPS
Assay data:21 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of human TLR4/MD2 complex in human THP1 cells assessed as induction of NFkappaB activation incubated for 18 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of human TLR4/MD2 complex expressed in HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay in presence of Rhodobacter sphaeroides LPS
Assay data:1 Tested
Activation of human TLR4 complex expressed in MD2-deficient HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay
Activation of human TLR4/MD2 complex expressed in CD14-deficient HEK293 Blue cells assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay
Activation of human TLR4/MD2 complex expressed in HEK293 Blue cells coexpressing CD14 assessed as SEAP secretion at 10 uM after 20 to 24 hrs by SEAPorter assay
Antagonist activity at TLR4 (unknown origin) expressed in HEK293 Blue cells measured after 2 to 4 hrs by spectrophotometry
Assay data:4 Tested
Antagonist activity at human TLR4 expressed in HEK293 cells co-transfected with human MD-2/CD14 assessed as inhibition of LPS-stimulated receptor signal after 2 to 4 hrs by dual luciferase reporter gene assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TLR4 expressed in HEK293 cells co-transfected with human MD-2/CD14 assessed as receptor signal after 2 to 4 hrs by dual luciferase reporter gene assay
Assay data:11 Tested
Agonist activity at TLR4 (unknown origin) expressed in HEK293 Blue cells measured after 2 to 4 hrs by spectrophotometry
Inhibition of LPS-induced TLR4 activation (unknown origin) expressed in HEK293 Blue cells compound treated for 30 mins prior LPS treatment measured after 2 to 4 hrs by spectrophotometry
Assay data:4 Active, 1 Activity ≤ 1 µM, 11 Tested
Agonist activity at human TLR4 in human THP1 cells assessed as induction of MyD88 signaling after 18 hrs by ELISA
Assay data:2 Active, 2 Tested
Agonist activity at human TLR4 expressed in HEK293 cells coexpressed with human MD2/CD14 assessed as activation of NFkappaB signaling at 10 ng/ml after 20 to 24 hrs by NFkappaB reporter assay
Agonist activity at human TLR4 expressed in HEK293 cells coexpressed with human MD2/CD14 assessed as activation of NFkappaB signaling after 20 to 24 hrs by NFkappaB reporter assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
TLR-pathway-human_P3C ligand_TNF readout
Assay data:143 Active, 756 Tested
Activation of TLR4/MD2 (unknown origin) expressed in HEK293 cells co-expressing CD14 assessed as induction of MyD88-dependent NF-kappaB activity after 24 hrs by NF-kappaB SEAP reporter gene assay
TLR-pathway-human_FLG ligand_TNF readout
Assay data:142 Active, 756 Tested
TLR-pathway-human_LPS ligand_TNF readout
Assay data:140 Active, 756 Tested
TLR-pathway-human_PGN ligand_TNF readout
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