BioAssay by Target (List) for Gene (Select 7015) - PubChem BioAssay - NCBI

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Select item 6317011.

Inhibition of telomerase in human A549 cells after 72 hrs by ELISA based TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:3 Tested

AID:: 631701

Summary PubMed Citation Related BioAssays by Target

Select item 5158142.

Inhibition of telomerase in human A549 cells at 25 uM after 24 hrs by TRAP assay in presence of 20 uM of intracellular calcium chelator BAPTA-AM pretreated for 1 hr

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Tested

AID:: 515814

Summary PubMed Citation Related BioAssays by Target

Select item 5158153.

Inhibition of telomerase in human A549 cells at 25 uM after 24 hrs by TRAP assay in presence of 20 uM of 26S proteasome inhibitor MG132 pretreated for 1 hr

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Active, 1 Tested

AID:: 515815

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 5158164.

Inhibition of telomerase in human A549 cells at 25 uM after 24 hrs by TRAP assay in presence of 20 nM of nuclear export inhibitor leptomycin B pretreated for 1 hr

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Active, 1 Tested

AID:: 515816

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 5158175.

Inhibition of telomerase in human A549 cells at 25 uM after 24 hrs by TRAP assay in presence of 50 uM of PI3 K inhibitor LY-294002 pretreated for 1 hr

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Active, 1 Tested

AID:: 515817

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 5166966.

Inhibition of telomerase in human SGC7901 cells by TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:6 Active, 10 Tested

AID:: 516696

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 5376017.

Inhibition of telomerase in human SGC7901 cells by TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:3 Active, 3 Tested

AID:: 537601

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 5875568.

Inhibition of human Telomerase activity in cell free system by TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:4 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 4 Tested

AID:: 587556

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5946369.

Inhibition of telomerase activity expressed in human SGC7901 cells by SYBER green dye based TRAP

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:3 Active, 8 Tested

AID:: 594636

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 61112310.

Inhibition of telomerase in human K562 cells at 20 uM using telo TAGGG telomerase PCR ELISA

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Tested

AID:: 611123

Summary PubMed Citation Related BioAssays by Target

Select item 62409911.

An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:497 Active, 21019 Tested

AID:: 624099

Summary PubMed Citation

Select item 63039712.

Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:18 Active, 20 Tested

AID:: 630397

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 51581313.

Inhibition of telomerase in human A549 cells at 25 uM after 24 hrs by TRAP assay in presence of 50 uM of MAPK inhibitor SB-203580 pretreated for 1 hr

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Active, 1 Tested

AID:: 515813

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 63170214.

Inhibition of telomerase in human A549 cells at 5 uM after 72 hrs by ELISA based TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:2 Tested

AID:: 631702

Summary PubMed Citation Related BioAssays by Target

Select item 63170915.

Inhibition of telomerase in human A549 cells at 0.05 to 100 uM after 72 hrs by ELISA based TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:1 Active, 1 Tested

AID:: 631709

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 63398416.

Inhibition of telomerase activity in human H1299 cell free extract at 10 uM by modified TRAP assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:40 Tested

AID:: 633984

Summary PubMed Citation Related BioAssays by Target

Select item 63398817.

Inhibition of human TERT in H1299 cells at 100 uM after 24 hrs by SEAP reporter gene assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:40 Tested

AID:: 633988

Summary PubMed Citation Related BioAssays by Target

Select item 63398918.

Inhibition of human TERT in H1299 cells at 10 uM after 24 hrs by SEAP reporter gene assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:40 Tested

AID:: 633989

Summary PubMed Citation Related BioAssays by Target

Select item 63399019.

Inhibition of human TERT in H1299 cells at 1 uM after 24 hrs by SEAP reporter gene assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:40 Tested

AID:: 633990

Summary PubMed Citation Related BioAssays by Target

Select item 64833820.

Inhibition of telomerase

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:2 Active, 3 Tested

AID:: 648338

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (185)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (72)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (135)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (351)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (351)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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