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Summary of the probe development effort to identify STAT5 inhibitors: luminescence-based cell-based reporter assay to identify inhibitors of STAT5 signaling
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assay
Assay data:8 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to full-length His-tagged STAT5B (unknown origin) by surface plasmon resonance assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Late stage assay provider assay for the probe development effort to identify STAT5 inhibitors: luminescence-based cell-based reporter assay to identify inhibitors of STAT5 signaling
Assay data:3 Active, 25 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of STAT5b DNA binding activity in IL-6 stimulated human MDA-MB-468 cells at 50 uM by transcription factor ELISA
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of STAT5b SH2 domain at 200 uM
Assay data:7 Tested
Inhibition of IL2-induced STAT5B phosphorylation in human YT cells at 30 ng/ml by immunoblotting analysis
Assay data:1 Active, 1 Tested
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
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