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Binding affinity to His-MBP-tagged human STAT4 (133 to 705 residues) expressed in Escherichia coli Rosette (DE3) assessed as dissociation constant using SD-45-FL as substrate measured after 1 hr by Fluorescence Polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/STAT4 in human SUP-M2 cells assessed as STAT4 degradation at 0.25 to 100 uM incubated for 4 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of STAT4 degradation in human SUP-M2 cells at 0.25 to 100 uM incubated for 14 hrs by Western blot analysis
Assay data:2 Tested
Protac activity at CRBN/STAT4 in human MOLM16 cells assessed as STAT4 degradation at 0.25 to 100 uM incubated for 4 hrs by Western blot analysis
Binding affinity to human recombinant STAT4 assessed as dissociation constant incubated for 15 mins by biolayer interferometry
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human His/SUMO-tagged STAT4 (133 to 705 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay
Protac activity at CRBN/STAT4 in human SUDHL1 cells assessed as degradation of STAT4 at 10 uM incubated for 18 hrs by Western blot analysis
Protac activity at CRBN/STAT4 in human SUDHL1 cells assessed as degradation of STAT4 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis
Protac activity at CRBN/STAT4 in human MOLM16 cells assessed as degradation of STAT4 at 10 uM incubated for 4 hrs by Western blot analysis
Protac activity at CRBN/STAT4 in human MOLM16 cells assessed as degradation of STAT4 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
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