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Inhibitory concentration against human somatostatin receptor type 5 in CHO-K1 cells
Assay data:12 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]11-Tyr somatostatin-14 from human SST5R expressed in CHO cells
Assay data:26 Active, 16 Activity ≤ 1 µM, 30 Tested
Agonist activity at human SST5 receptor expressed in CHOK1 cells assessed as effect on forskolin-induced cAMP production
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [125I][Leu8-D-Trp22, Tyr25]-SRIF28 from human SST5 receptor
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [125I-Tyr-11]-SRIF from SSTR of human NCI-H69 cell membranes
Assay data:7 Active, 4 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Affinity for somatostatin receptors
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of sst receptor at 10 uM
Inhibition of sst receptor at 1 uM
Inhibition of [125I](Leu8,DTrp22,Tyr25)-SRIF28 binding to human sst5
Assay data:5 Active, 6 Activity ≤ 1 µM, 6 Tested
Binding affinity to somatostatin receptor by radioligand binding assay
Assay data:2 Tested
Antagonist activity at human SST5R expressed in CHO cells assessed as reversal of somatostatin-14 induced cAMP response
Binding affinity for SRIF (somatostatin) receptor
Assay data:5 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 11 Tested
Binding affinity towards somatostatin receptor type 5
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst5 receptor
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=6)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=5)
In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3)
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=2)
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 5
Assay data:5 Active, 45 Activity ≤ 1 µM, 45 Tested
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 5
Assay data:7 Active, 49 Activity ≤ 1 µM, 49 Tested
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