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Binding affinity to NDKB in human K562 cells at 1 mM incubated for 2 hrs by LC-MS/MS analysis based pull down assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to NME2 in human SUM159 cell lysates by multiplexed inhibitor bead profiling-based LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to NME1-NME2 in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay
Binding affinity to NM23-H2 in human SiHa cells assessed as disruption of protein interaction with c-myc G-quadruplex DNA by measuring decrease in c-MYC protein level at 4 uM after 48 hrs by Western blot method
Assay data:2 Active, 2 Tested
Binding affinity to NM23-H2 in human SiHa cells assessed as disruption of protein interaction with c-myc G-quadruplex DNA by measuring decrease in c-MYC protein expresson at 2 uM after 48 hrs by Western blot analysis
Binding affinity to NM23-H2 in human SiHa cells assessed as disruption of protein interaction with c-myc G-quadruplex DNA by measuring decrease in c-MYC mRNA level at 2 uM after 9 hrs by RT-PCR analysis
Binding affinity to NM23-H2 (unknown origin) up to 40 uM by SPR analysis
Assay data:17 Tested
Binding affinity to NM23-H2 in human SiHa cells assessed as disruption of protein interaction with c-myc G-quadruplex DNA by measuring decrease in c-MYC protein expresson at 1 to 2 uM after 48 hrs by Western blot analysis
Binding affinity to NM23-H2 in human SiHa cells assessed as disruption of protein interaction with c-myc G-quadruplex DNA by measuring decrease in c-MYC mRNA level after 9 hrs by RT-PCR analysis
Binding affinity to NM23-H2 (unknown origin) assessed as reduction in protein interaction with Pu22 c-myc G-quadruplex DNA after 1 hr by EMSA
Binding affinity to NM23-H2 (unknown origin) assessed as ratio of Kd for protein interaction with biotin-labeled Pu22 c-myc G-quadruplex DNA in presence and absence of compound after 1 hr by ELISA
Binding affinity to N-terminal NT-647-NHS labeled NM23-H2 H118F mutant (unknown origin) after 30 mins by MST analysis
Binding affinity to NM23-H2 H118F mutant (unknown origin) by SPR analysis
Binding affinity to N-terminal NT-647-NHS labeled NM23-H2 G113F mutant (unknown origin) after 30 mins by MST analysis
Binding affinity to NM23-H2 G113F mutant (unknown origin) by SPR analysis
Binding affinity to N-terminal NT-647-NHS labeled NM23-H2 D54A mutant (unknown origin) after 30 mins by MST analysis
Binding affinity to NM23-H2 D54A mutant (unknown origin) by SPR analysis
Binding affinity to N-terminal NT-647-NHS labeled NM23-H2 (unknown origin) after 30 mins by MST analysis
Assay data:5 Active, 47 Tested
Binding affinity to NM23-H2 (unknown origin) by SPR analysis
Assay data:7 Active, 31 Tested
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