BioAssay by Target (List) for Gene (Select 6513) - PubChem BioAssay - NCBI

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Select item 19151671.

Selectivity interaction (Proliferation assay (HelaMa TU cells)) EUB0000307b SLC2A1

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915167

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19130312.

Affinity On-target Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (DLD1 cells; Promega)) EUB0000307b SLC2A1

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913031

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19130283.

Affinity On-target Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (DLD1 cells; Promega)) EUB0000251b SLC2A1

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Tested

AID:: 1913028

Summary Compounds, Active Related BioAssays by Target

Select item 19128384.

Affinity Phenotypic Cellular interaction (Cellular mechanistic assay (inhibition of glucose uptake by Hela-MaTu cells)) EUB0000307b SLC2A1

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912838

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19124635.

Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells (PubChem AID: 1794830)

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:4 Tested

AID:: 1912463

Summary Related BioAssays by Target

Select item 18150066.

Induction of GLUT1-mediated HEK293T cytotoxicity assessed as cell viability at 3.125 uM incubated for 24 hrs by CCK-8 assay

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 2 Tested

AID:: 1815006

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18150047.

Induction of GLUT1-mediated human A549 cell cytotoxicity assessed as cell viability at 12.5 uM incubated for 24 hrs by CCK-8 assay

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:2 Active, 2 Tested

AID:: 1815004

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18150038.

Induction of GLUT1-mediated human HeLa cell cytotoxicity assessed as cell viability at 12.5 uM incubated for 24 hrs by CCK-8 assay

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:2 Active, 2 Tested

AID:: 1815003

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18149889.

Binding affinity to GLUT1 (unknown origin) assessed as binding free energy

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:8 Tested

AID:: 1814988

Summary PubMed Citation Related BioAssays by Target

Select item 181498710.

Binding affinity to GLUT1 (unknown origin) membrane assessed as free energy

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:8 Tested

AID:: 1814987

Summary PubMed Citation Related BioAssays by Target

Select item 180461011.

ATP Assay from US Patent US10729691: "Treatment of infectious diseases with glucose uptake inhibitors"

Source:: BindingDB

Protein Targets:: Solute carrier family 2, facilitated glucose transporter member 1; ...
Total:: 1

Assay data:59 Active, 59 Activity ≤ 1 µM, 59 Tested

AID:: 1804610

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180179012.

[3H]-2-Deoxy-D-glucose ([3H]-2-DG) Uptake Assay from Article 10.1021/acschembio.6b00304: "Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening."

Source:: BindingDB

Protein Targets:: Solute carrier family 2, facilitated glucose transporter member 1; ...
Total:: 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 8 Tested

AID:: 1801790

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 179483013.

Flow cytometry transport assay for SLC2A1 using HEK293 JumpIN TRex SLC2A1 WT-OE cells

Source:: RESOLUTE - Research Empowerment on Solute Carriers

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1794830

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 178916114.

Cellular mechanistic assay: Inhibition of glucose uptake by Hela-MaTu cells

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1789161

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 178915715.

Cell-based assay with CellTiter-Glo readout for ATP production with SLC2A1

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1789157

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 174036416.

Inhibition of GLUT1 in human CCRF-CEM cells assessed as upregulation of GRP78 expression at 10 uM measured after 6 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Tested

AID:: 1740364

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 174036317.

Inhibition of GLUT1 in human CCRF-CEM cells assessed as decrease in CDK2 phosphorylation at 10 uM measured after 6 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Tested

AID:: 1740363

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 174036218.

Inhibition of GLUT1 in human CCRF-CEM cells assessed as decrease in mTOR phosphorylation at 10 uM measured after 6 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Tested

AID:: 1740362

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 174034319.

Inhibition of transport activity of human GLUT1 expressed in hexose transporter deficient VW4000fgy1 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells by measuring relative activity at 100 uM measured after 10 mins by scintillation counting method relative to control

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Tested

AID:: 1740343

Summary PubMed Citation Related BioAssays by Target

Select item 174034020.

Inhibition of transport activity of human GLUT1 expressed in hexose transporter deficient VW4000fgy1 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells measured after 10 mins by scintillation counting method

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:3 Tested

AID:: 1740340

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (69)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (22)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (42)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (100)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (87)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (26)
BioAssays deposited by other experimentalists

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