BioAssay by Target (List) for Gene (Select 6334) - PubChem BioAssay - NCBI

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Select item 19601461.

Inhibition of human Nav1.6 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated voltage clamp electrophysiology technique

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1960146

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19220372.

Inhibition of Nav1.6 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1922037

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19199413.

Qube Assay from US Patent US11802122: "2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 8 subunit alpha; ...
Total:: 1

Assay data:104 Active, 4 Activity ≤ 1 nM, 99 Activity ≤ 1 µM, 105 Tested

AID:: 1919941

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19198044.

Qube Assay from US Patent US20230312528: "2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 8 subunit alpha; ...
Total:: 1

Assay data:172 Active, 5 Activity ≤ 1 nM, 156 Activity ≤ 1 µM, 176 Tested

AID:: 1919804

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19194915.

Assays for Detecting and Measuring of NaV Inhibition from US Patent US11673864: "Pyridone amides as modulators of sodium channels"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 8 subunit alpha; ...
Total:: 1

Assay data:149 Active, 1 Activity ≤ 1 nM, 112 Activity ≤ 1 µM, 159 Tested

AID:: 1919491

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19194206.

Electrophysiological Assay (In Vitro Assay) from US Patent US11639351: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 8 subunit alpha; ...
Total:: 1

Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1919420

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19194197.

Sodium Influx Assay (In Vitro Assay) from US Patent US11639351: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 1 subunit alpha; ...
Total:: 3

Assay data:47 Active, 28 Activity ≤ 1 µM, 48 Tested

AID:: 1919419

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18916488.

Inhibition of human Nav 1.8 by manual electrophysiology method

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1891648

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18915719.

Inhibition of human Nav1.8 by FRET based membrane potential assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested

AID:: 1891571

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188026910.

Inhibition of human Nav1.8 channel stably expressed in HEK293 cells assessed as sodium current flow at holding potential of -90mV by whole-cell voltage clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1880269

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187580611.

Inhibition of human Nav1.8 expressed in CHO cells at -120 mV holding potential by automated patch clamp electrophysiology recording

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:1 Tested

AID:: 1875806

Summary PubMed Citation Related BioAssays by Target

Select item 185759512.

Inhibition of NaV1.8 (unknown origin) cardiac ion channel by patch clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1857595

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 183165113.

Inhibition of human Nav1.6 expressed in CHO cells by whole cell voltage clamp analysis

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1831651

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 181859714.

Inhibition of human Nav1.6 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -85 mV by whole-cell Qube-automated patch clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:6 Active, 1 Activity ≤ 1 µM, 24 Tested

AID:: 1818597

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180652315.

Electrophysiological Assay (In Vitro Assay) from US Patent US11325902: "Benzenesulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 8 subunit alpha; ...
Total:: 1

Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested

AID:: 1806523

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180644616.

Electrophysiological Assay (In Vitro Assay) from US Patent US11299490: "Benzenesulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 1 subunit alpha; ...
Total:: 3

Assay data:82 Active, 1 Activity ≤ 1 nM, 71 Activity ≤ 1 µM, 83 Tested

AID:: 1806446

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180611817.

Electrophysiological Assay (In Vitro Assay) from US Patent US11174268: "Benzenesulfonamide compouds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 1 subunit alpha; ...
Total:: 3

Assay data:134 Active, 2 Activity ≤ 1 nM, 127 Activity ≤ 1 µM, 134 Tested

AID:: 1806118

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180611718.

Sodium Influx Assay (In Vitro Assay) from US Patent US11174268: "Benzenesulfonamide compouds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 1 subunit alpha; ...
Total:: 3

Assay data:327 Active, 1 Activity ≤ 1 nM, 231 Activity ≤ 1 µM, 333 Tested

AID:: 1806117

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180547819.

Electrophysiological Assay (In Vitro Assay) from US Patent US10981905: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 8 subunit alpha; ...
Total:: 1

Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1805478

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180547720.

Sodium Influx Assay (In Vitro Assay) from US Patent US10981905: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 1 subunit alpha; ...
Total:: 3

Assay data:48 Active, 28 Activity ≤ 1 µM, 49 Tested

AID:: 1805477

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (77)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (12)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (50)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (86)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (169)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (158)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (23)
BioAssays deposited by other experimentalists

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