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Antagonist activity at human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-C11-rUU-C7-BHQ2 as substrate by FRET assay in presence of natural activator pAAAA
Assay data:45 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of human recombinant RNase L assessed as cleavage of FRET RNA probe at until 60 to 90 mins
Assay data:2 Tested
Activation of human recombinant RNase L assessed as cleavage of p32-labelled RNA molecule at 25 uM after 30 mins
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human recombinant RNase L
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage
Assay data:3 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of human RNaseL ANK domain expressed in Escherichia col assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage relative to control
Assay data:6 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET assay
Assay data:12 Active, 22 Activity ≤ 1 µM, 22 Tested
Activation of human recombinant RNase L assessed as cleavage of FRET RNA probe at 15 mins
Assay data:1 Active, 1 Tested
AT1R-EGFR transactivation kinome screen - primary
Assay data:50 Active, 714 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed as substrate cleavage measured for 50 mins by FRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Human kinome siRNA screen in A549-BTR and MDA-231-1833-BTR cells
Assay data:49 Active, 714 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
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