BioAssay by Target (List) for Gene (Select 599) - PubChem BioAssay - NCBI

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Select item 6284901.

Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 628490

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 11561022.

Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1156102

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 11408853.

Displacement of Flu-BID/FAM-BID from His-tagged BCLW (1 to 155) (unknown origin) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:6 Active, 7 Tested

AID:: 1140885

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 11173574.

InfectX: Pathogen infection siRNA screens

Source:: InfectX Consortium

Assay data:115372 Tested

AID:: 1117357

Summary PubMed Citation

Select item 11172815.

A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:555 Active, 64752 Tested

AID:: 1117281

Summary PubMed Citation

Select item 10751386.

Inhibition of binding of wild type mBIMBH3 peptide to human Bcl-W delta C29 (C29S/A128E) mutant by surface plasmon resonance competition experiment

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:2 Tested

AID:: 1075138

Summary PubMed Citation Related BioAssays by Target

Select item 7567647.

Binding affinity to Bcl-w (unknown origin) by luminescence proximity assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:1 Tested

AID:: 756764

Summary PubMed Citation Related BioAssays by Target

Select item 7567568.

Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:3 Active, 1 Activity ≤ 1 µM, 9 Tested

AID:: 756756

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7434549.

RNAi screen for vorinostat resistance genes - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:450 Active, 18118 Tested

AID:: 743454

Summary PubMed Citation

Select item 74312110.

Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:167 Active, 26449 Tested

AID:: 743121

Select item 70152611.

Binding affinity to Bcl-w

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 701526

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 67107412.

Inhibition of Bcl-w

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 671074

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 65181113.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:9227 Active, 64752 Tested

AID:: 651811

Summary PubMed Citation

Select item 65181014.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:826 Active, 18119 Tested

AID:: 651810

Summary PubMed Citation

Select item 115950615.

Identification of proteins required for the processing of the EWS-FLI1 nascent transcript

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59220 Tested

AID:: 1159506

Select item 62409916.

An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:497 Active, 21019 Tested

AID:: 624099

Summary PubMed Citation

Select item 58701117.

Displacement of wild type mBimBH3 from human Bcl-w by solution competition assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:5 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 587011

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 34002218.

Inhibition of 5-carboxyfluorescein-labeled Flu-Bak-BH3 peptide binding to Bcl-w by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:1 Active, 3 Tested

AID:: 340022

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 33073619.

Inhibition of BH3 peptide binding to human recombinant BCL-w by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 330736

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 31674220.

Inhibition of Bak peptide binding to human recombinant Bcl-w

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 2

Assay data:3 Active, 10 Tested

AID:: 316742

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (31)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (24)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (39)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (42)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (4)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (39)
BioAssays extracted from the literature
NIH MLP (4)
BioAssays deposited by the NIH Molecular Libraries Program
Other (12)
BioAssays deposited by other experimentalists

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