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Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins
Assay data:17 Active, 10 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
SummaryPubMed Citation
Antagonist activity at human TRPV4
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Agonist activity at human TRPV4 expressed in CHOK1 cells assessed as changes in intracellular calcium level measured for 5 mins by FLIPR assay
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonist activity at human TRPV4 expressed in CHOK1 cells assessed as inhibition of PF-04674114/GSK1016790A-induced changes in intracellular calcium level measured for 5 mins by FLIPR assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of hypotonic solution-induced Ca2+ influx
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx
Agonist activity at human TRPV4 expressed in HEK cells by aequorin Luminescence/summary (Abse5) assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins
Antagonist activity at human TRPV4 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of 4alpha-PDD-induced Ca2+ influx up to 10 uM preincubated for 2.5 mins followed by 4alpha-PDD addition measured for 1 min by luminescence assay
Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activation
Assay data:37 Active, 6 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
Antagonist activity at human TRPV4 assessed as inhibition of hypotonicity-induced activation
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human TRPV4 expressed in CHO cells assessed as inhibition of capsaicin-induced response
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FLIPR assay
Assay data:27 Active, 24 Activity ≤ 1 µM, 31 Tested
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