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PubChem BioAssay

Biological Activity

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Items: 1 to 20 of 34

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Select item 945481.

Inhibitory constant against Kynurenine 3-hydroxylase

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 94548

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2211872.

Compound was evaluated for inhibition of rat liver KYN 3-OHase

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Tested

AID:: 221187

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 2190023.

Compound was evaluated for the inhibition of rat brain KYN 3-OHase

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 219002

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2190014.

Inhibition of rat brain KYN 3-OHase.

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:14 Active, 6 Activity ≤ 1 µM, 14 Tested

AID:: 219001

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2190005.

Compound was evaluated for inhibition of rat brain KYN 3-OHase

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 219000

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 945526.

Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver at 10 uM

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:28 Tested

AID:: 94552

Summary PubMed Citation Related BioAssays by Target

Select item 945517.

Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:26 Active, 6 Activity ≤ 1 µM, 27 Tested

AID:: 94551

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 945508.

Ability to inhibit kynurenine-3-hydroxylase was determined in a competitive inhibition assay.

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 94550

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 945499.

Differences in inhibition of kynurenine-3-hydroxylase by m-NBA versus compound is determined

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:4 Tested

AID:: 94549

Summary PubMed Citation Related BioAssays by Target

Select item 22118810.

Inhibition of rat liver KYN 3-OHase.

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:11 Active, 1 Activity ≤ 1 µM, 19 Tested

AID:: 221188

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9454711.

Tested for inhibitory activity against kynurenine 3-hydroxylase at 100 uM concentration

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Tested

AID:: 94547

Summary Related BioAssays by Target

Select item 9454612.

Inhibition of rat kidney Kynurenine 3-hydroxylase.

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested

AID:: 94546

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9454513.

Tested for inhibitory activity against kynurenine 3-hydroxylase

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 94545

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 9454414.

Tested for inhibitory activity against Kynurenine 3-hydroxylase

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 94544

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 9454315.

Compound was evaluated for ex vivo inhibition of Kynurenine 3-hydroxylase activity in liver of rat after injecting perorally

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:5 Tested

AID:: 94543

Summary PubMed Citation Related BioAssays by Target

Select item 9454216.

Compound was evaluated for ex vivo inhibition of Kynurenine 3-hydroxylase activity in kidney of rat after injecting perorally

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:5 Tested

AID:: 94542

Summary PubMed Citation Related BioAssays by Target

Select item 9454117.

Compound was evaluated for ex vivo inhibition of Kynurenine 3-hydroxylase activity in kidney and liver of rat after injecting perorally

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Tested

AID:: 94541

Summary PubMed Citation Related BioAssays by Target

Select item 65918918.

Inhibition of kynurenine-3-hydroxylase in rat liver homogenates assessed as effect on production of 3-hydroxy kynurenine up to 125 uM incubated for 1 hr by HPLC

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Tested

AID:: 659189

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 147355919.

Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrate

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1473559

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 144473020.

Inhibition of rat KMO

Source:: ChEMBL

Protein Target:: Kynurenine 3-monooxygenase

Assay data:1 Active, 1 Tested

AID:: 1444730

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (23)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (18)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (23)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (34)
BioAssays extracted from the literature

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BioAssay by Target (List) for Gene (Select 59113) (34)
PubChem BioAssay
Mus musculus RAS related protein 2a (Rap2a), mRNA
Mus musculus RAS related protein 2a (Rap2a), mRNA
gi|118130630|ref|NM_029519.3|

Nucleotide
Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 [Rattus norvegicus]
Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 [Rattus norvegicus]
Gene ID:64539

Gene
64539[uid] AND (alive[prop]) (1)
Gene

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