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Inhibition of non-lysosomal glucosylceramidase
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
SummaryPubMed Citation
Inhibition of beta-glucosidase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Induction of wild type beta glucosidase activity in fibroblasts derived from Gaucher disease patient after 4 days relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of wild type human beta glucosidase activity expressed in monkey COS7 cells at 10 uM relative to control
Inhibition of beta glucosidase (unknown origin)
Induction of beta glucosidase L444P mutant activity in fibroblasts derived from Gaucher disease patient at 30 uM relative to control
Assay data:3 Tested
Induction of beta glucosidase L444P mutant activity in fibroblasts derived from Gaucher disease patient using 4MUG as substrate relative to control
Binding affinity to beta glucosidase (unknown origin) relative to control
Induction of beta glucosidase L444P mutant activity in fibroblast derived from Gaucher disease patient relative to control
Induction of beta glucosidase L444P mutant activity in lymphoblast derived from Gaucher disease patient at 1 nM after 3 days relative to control
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Inhibition of non-lysosomal glucosylceramidase in cultured melanoma cells
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis
Assay data:10 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 53 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay
Assay data:26 Active, 1 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
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