BioAssay by Target (List) for Gene (Select 5733) - PubChem BioAssay - NCBI

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Select item 4349741.

Late-stage radioligand binding assay to identify inhibitors of NADPH oxidase 1 (NOX1): PDSP screen

Source:: The Scripps Research Institute Molecular Screening Center

Protein Targets:: 5-hydroxytryptamine (serotonin) receptor 1A; ...
Total:: 58

Assay data:1 Active, 1 Tested

AID:: 434974

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 4677902.

Antagonist activity at human EP3 receptor at 0.1 uM by FLIPR assay

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:3 Tested

AID:: 467790

Summary PubMed Citation Related BioAssays by Target

Select item 4677893.

Antagonist activity at human EP3 receptor at 1 uM by FLIPR assay

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:1 Tested

AID:: 467789

Summary PubMed Citation Related BioAssays by Target

Select item 4677884.

Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:23 Tested

AID:: 467788

Summary PubMed Citation Related BioAssays by Target

Select item 4677875.

Displacement of [3H]PGE2 from human EP3 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:25 Active, 4 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 26 Tested

AID:: 467787

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4677866.

Full displacement of [3H]PGE2 from human EP3 receptor at 20 uM

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:1 Tested

AID:: 467786

Summary PubMed Citation Related BioAssays by Target

Select item 4590087.

Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293-EBNA cells by scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:4 Activity ≤ 1 µM, 11 Tested

AID:: 459008

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4456688.

Displacement of [3H]PGE2 from human EP3 receptor after 60 mins repeated washing by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 445668

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4456599.

Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:54 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 57 Tested

AID:: 445659

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 44565810.

Displacement of [3H]PGE2 from human EP3 receptor at 1 uM after 1 hr by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:3 Tested

AID:: 445658

Summary PubMed Citation Related BioAssays by Target

Select item 44565711.

Antagonist activity at human EP3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP level after 10 mins by EIA

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 445657

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 44565612.

Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting in presence of 10% human serum

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:33 Active, 16 Activity ≤ 1 µM, 33 Tested

AID:: 445656

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 44565513.

Ratio of IC50 for human EP3 receptor in presence of 10% human serum to IC50 for human EP3 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:34 Tested

AID:: 445655

Summary PubMed Citation Related BioAssays by Target

Select item 46779114.

Antagonist activity at human EP3 receptor at 10 uM by FLIPR assay

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:2 Tested

AID:: 467791

Summary PubMed Citation Related BioAssays by Target

Select item 43136115.

Antagonist activity against prostaglandin E3 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:1 Tested

AID:: 431361

Summary PubMed Citation Related BioAssays by Target

Select item 43020516.

Inhibition of human EP3 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 430205

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 43020417.

Agonist activity at human EP3 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:1 Tested

AID:: 430204

Summary PubMed Citation Related BioAssays by Target

Select item 43019318.

Antagonist activity at human EP3 receptor expressed in cells assessed as mobilization of intracellular calcium by FLIPR assay

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:22 Active, 20 Activity ≤ 1 µM, 24 Tested

AID:: 430193

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 41788019.

Antagonist activity at human EP3-2 receptor expressed in CHOK1 cells

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 417880

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 41786720.

Ratio IC50 for human EP3 receptor in presence of human serum to IC50 for human EP3 in absence of human serum

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP3 subtype

Assay data:36 Tested

AID:: 417867

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (2)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (113)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (20)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (84)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (134)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (189)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (173)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (27)
BioAssays deposited by other experimentalists

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