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MAPK1 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
MAPK1 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of ERK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ERK1/2 pathway in human A549/Taxol cells assessed as decrease in phosphorylated ERK1/2 level at 2.5 to 5 uM incubated for 24 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ERK1/2 pathway in human A549/Taxol cells assessed as decrease in phosphorylated ERK1/2 level at 5 uM incubated for 24 hrs
Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human MV4-11 cells at 0.1 uM incubated for 1 hrs by immunoblotting analysis
Inhibition of ERK2 (unknown origin)
Inhibition of ERK2 (unknown origin) at 100 uM preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assay relative to control
Assay data:24 Tested
Inhibition of Erk2 (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
p38 Inhibitory Potency Assay from US Patent US11844801: "Oral compositions of MK2 pathway inhibitor for treatment of immune conditions"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ERK2 Enzymatic Assay from US Patent US11708364: "Azaindole derivatives and their use as ERK kinase inhibitors"
Assay data:90 Active, 92 Activity ≤ 1 µM, 92 Tested
Biochemical Assay (10 uM) from US Patent US11685719: "Pyridinone MK2 inhibitors and uses thereof"
Assay data:23 Active, 5 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical Assay (1 uM) from US Patent US11685719: "Pyridinone MK2 inhibitors and uses thereof"
Assay data:23 Active, 2 Activity ≤ 1 µM, 24 Tested
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b MAPK1
Selectivity interaction (Enzymatic assay) EUB0000609a MAPK1
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (Ambit kinase binding assay panel) EUB0000609a MAPK1
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