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Binding affinity to human recombinant His-tagged ADCY10 assessed as dissociation rate constant (koff) and measured for 600 sec by SPR analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human recombinant His-tagged ADCY10 assessed as association rate constant (kon) and measured for 120 sec by SPR analysis
Binding affinity to human recombinant GST-tagged ADCY10 assessed as residence time by cAMP level preincubated for 15 mins followed by substrate addition and measured after 1 hr using alpha-32P ATP as substrate by sequential chromatographic analysis
Assay data:3 Tested
Binding affinity to human recombinant His-tagged ADCY10 assessed as residence time and measured for 600 sec by SPR analysis
Assay data:12 Tested
Binding affinity to human recombinant His-tagged ADCY10 assessed as dissociation constant and measured for 600 sec by SPR analysis
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human ADCY10 assessed as cAMP accumulation at 500 uM preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Assay data:31 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 31 Tested
Inhibition of human ADCY10
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
ELISA-based Correlate-EIA Direct cAMP Assay from US Patent US10981899: "Inhibitors of soluble adenylyl cyclase"
Assay data:3 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
RF-MSS cyclase assay from US Patent US10981899: "Inhibitors of soluble adenylyl cyclase"
Assay data:2 Active, 4 Tested
Inhibition of human soluble adenylyl cyclase transfected (4-4 clones)in human HEK293 cells assessed as reduction in cAMP levels preincubated for 5 mins with test compounds in the presence of IBMX by ELISA
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Potency index, ratio of IC50 for LRE1 to IC50 for test compound for inhibition of human soluble adenylyl cyclase
Assay data:1 Tested
Inhibition of human soluble adenylyl cyclase assessed as reduction in cAMP levels in the presence of alpha-32p labeled ATP by biochemical assay
Assay data:16 Active, 16 Activity ≤ 1 µM, 22 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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