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Partial agonist activity at PPARalpha (unknown origin) assessed as increase in fluorescein labeled SMRT corepressor peptide requirement by Lanthascreen TR-FRET assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Partial agonist activity at PPARalpha (unknown origin) assessed as increase in PRIP/RAP250 coactivator peptide requirement by Lanthascreen TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to PPARalpha (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Displacement of fluormone pan-PPARgreen from PPARalpha (unknown origin) at 30 uM by TR-FRET based competitive binding assay relative to control
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FABP1 mRNA levels at 10 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in PDK4 mRNA levels at 250 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FABP1 mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FGF21 mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as effect on ABCA1 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis
Assay data:1 Tested
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FABP1 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in PDK4 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FGF21 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in HMGCS2 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis
Agonist activity at yeast Gal4-fused human PPARalpha LBD transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry relative to control
Assay data:23 Tested
Agonist activity at yeast Gal4-fused human PPARalpha LBD transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry
Assay data:19 Active, 9 Activity ≤ 1 µM, 26 Tested
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in liver CPT1a mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in HMGCS2 mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis
Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as effect on liver CPT1a mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis
Stabilization of human PPARalpha LBD assessed as change in melting temperature at 50 uM by thermal shift assay
Stabilization of human PPARalpha LBD assessed as change in melting temperature at 25 uM by thermal shift assay
Assay data:6 Tested
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