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Substrate activity at human OCT2 overexpressed in HEK293 cells assessed as uptake ratio incubated for 2 mins by LC-MS/MS analysis
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at human OCT2 overexpressed in HEK293 cells at 2.5 uM incubated for 2 mins by LC-MS/MS analysis
Assay data:6 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of OCT2 mediated (unknown origin) assessed as intracellular accumulation of ASP+ relative to control
Assay data:4 Tested
Inhibition Assay from US Patent US10689399: "Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections"
Assay data:19 Active, 11 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9795602: "Polycyclic-carbamoylpyridone compounds and their pharmaceutical use"
Assay data:4 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of OCT2 (unknown origin) expressed in HEK293 cells
Assay data:1 Tested
Inhibition of human OCT2 assessed as reduction in intracellular probe substrate accumulation upto 100 uM by microplate scintillation counter analysis relative to control
Inhibition of human OCT2 assessed as reduction in OCT2-mediated metformin transport at 14900 uM relative to control
Inhibition of OCT2 (unknown origin) up to 50 uM
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Drug transport in human OCT2 expressed in HEK Flp-In cells at 0.009 uM for 10 mins relative to control
Transport efficiency, ratio of maximal rate of transport to Km for drug transport in human OAT2 expressed in HEK Flp-In cells measured per mg of protein
Drug transport in human OAT2 expressed in HEK Flp-In cells
Assay data:1 Active, 4 Tested
Drug transport in human OAT2 expressed in HEK Flp-In cells assessed as maximal rate of transport measured per mg of protein
Drug transport in human OCT2 expressed in HEK Flp-In cells at 0.06 uM for 10 mins relative to control
Drug transport in human OCT2 expressed in HEK Flp-In cells at 0.07 uM for 10 mins relative to control
Drug transport in human OCT2 expressed in HEK Flp-In cells at 0.19 uM for 10 mins relative to control
Inhibition of OCT2 (unknown origin) expressed in HEK293 cells assessed as reduction of [ethyl 1-14C]TEA substrate uptake at 100 uM by liquid scintillation counting
Inhibition of OCT2 (unknown origin) expressed in HEK293 cells assessed as reduction of [14C]metformin substrate uptake at 100 uM by liquid scintillation counting
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