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Inhibition of PRMT7 (unknown origin) by radioisotope based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000226b PRMT7
SummaryRelated BioAssays by Target
Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PRMT7 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of N-terminal His-tagged full-length recombinant human PRMT7 (2 to 692 residues) expressed in baculovirus expression system at 1 uM using 3H-SAM as a substrate relative to control
Inhibition of human recombinant full length N-terminal his-tagged PRMT7 (2 to 692 residues) expressed in baculovirus at 50 uM by scintillation/filter plate assay relative to control
Inhibition of human recombinant full length N-terminal his-tagged PRMT7 (2 to 692 residues) expressed in baculovirus at 10 uM by scintillation/filter plate assay
Inhibition of PRMT7 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
In Vitro Enzymatic Assay from Article 10.1111/cbdd.12881: "Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations."
Assay data:5 Active, 1 Activity ≤ 1 µM, 13 Tested
Inhibition of recombinant human N-terminal His-tagged full length PRMT7 (2 to 692 residues) expressed in baculovirus system using GST-GAR as substrate at 10 uM by radiometric HotSpot assay relative to control
Inhibition of recombinant human PRMT7 using GST-GAR as substrate by hotspot assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli assessed as residual activity at 10 uM using biotin-labeled SMD1 as substrate incubated for 120 mins in presence of [3H]-SAM cofactor by scintillation proximity assay relative to control
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mins in presence of [3H]-SAM cofactor by scintillation proximity assay
Assay data:5 Tested
Inhibition of PRMT7 (unknown origin) using biotin-labeled histone substrate assessed as residual activity at 50 uM in presence of [3H-Me]SAM by scintillation proximity assay relative to control
Assay data:24 Tested
Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate and [3H]SAM addition and measured after 240 mins by microbeta method
Inhibition of recombinant full-length human PRMT7 expressed in Sf9 insect cells using Ac-KKDGKKRKRSRKESYK-biotin as substrate measured after 30 mins in presence of SAM by topcount scintillation counting method
Inhibition of human PRMT7 up to 50 uM using Biot-H2B (23-37) as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay
Inhibition of PRMT7 (unknown origin) at 50 uM assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 50 uM incubated for 1 hr by scintillation proximity assay relative to control
Inhibition of PRMT7 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay
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