BioAssay by Target (List) for Gene (Select 54331) - PubChem BioAssay - NCBI

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Select item 12248301.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:2853 Active, 18113 Tested

AID:: 1224830

Summary Related BioAssays by Same Project

Select item 19042.

siRNA Circadian Assay

Source:: The Genomics Institute of the Novartis Research Foundation (GNF)

Assay data:527 Active, 33364 Tested

AID:: 1904

Summary PubMed Citation Related BioAssays by Depositor

Select item 6240993.

An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:497 Active, 21019 Tested

AID:: 624099

Summary PubMed Citation

Select item 6518104.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:826 Active, 18119 Tested

AID:: 651810

Summary PubMed Citation

Select item 6518115.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:9227 Active, 64752 Tested

AID:: 651811

Summary PubMed Citation

Select item 7431216.

Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:167 Active, 26449 Tested

AID:: 743121

Select item 7434547.

RNAi screen for vorinostat resistance genes - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:450 Active, 18118 Tested

AID:: 743454

Summary PubMed Citation

Select item 11172818.

A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:555 Active, 64752 Tested

AID:: 1117281

Summary PubMed Citation

Select item 11173579.

InfectX: Pathogen infection siRNA screens

Source:: InfectX Consortium

Assay data:115372 Tested

AID:: 1117357

Summary PubMed Citation

Select item 115950610.

Identification of proteins required for the processing of the EWS-FLI1 nascent transcript

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59220 Tested

AID:: 1159506

Select item 115957811.

A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:1034 Active, 18120 Tested

AID:: 1159578

Summary Related BioAssays by Depositor

Select item 115958412.

A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:2442 Active, 18052 Tested

AID:: 1159584

Summary PubMed Citation

Select item 155977213.

Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:6 Active, 4 Activity ≤ 1 µM, 7 Tested

AID:: 1559772

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 126008014.

Inhibition of SIGKAFKILGYPDYD binding to biotinylated Gbeta1gamma2 (unknown origin) incubated for 1 hr by phage ELISA

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:12 Active, 9 Activity ≤ 1 µM, 34 Tested

AID:: 1260080

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 126008115.

Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PI3Kgamma activation incubated for 16 hrs

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:4 Active, 7 Tested

AID:: 1260081

Summary Compounds, Active Related BioAssays by Target

Select item 126008216.

Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PLCbeta3 activation incubated for 16 hrs

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:1 Active, 7 Tested

AID:: 1260082

Summary Compounds, Active Related BioAssays by Target

Select item 126008317.

Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PLCbeta2 activation incubated for 16 hrs

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:1 Active, 6 Tested

AID:: 1260083

Summary Compounds, Active Related BioAssays by Target

Select item 126008418.

Inhibition of biotinylated Gbeta1gamma2 (unknown origin) binding to PLCbeta2 at 10 uM incubated for 16 hrs

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1260084

Summary Compounds, Active Related BioAssays by Target

Select item 126008519.

Inhibition of biotinylated Gbeta1gamma2 (unknown origin) binding to PLCbeta2 at 1 uM incubated for 16 hrs

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:1 Tested

AID:: 1260085

Summary Related BioAssays by Target

Select item 126008620.

Inhibition of biotinylated Gbeta1gamma2 (unknown origin) binding to PLCbeta3 at 10 uM incubated for 16 hrs

Source:: ChEMBL

Protein Targets:: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1260086

Summary Compounds, Active Related BioAssays by Target

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (7)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (2)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (5)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (11)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (1)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (22)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 54331) (24)
PubChem BioAssay
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [Ho...
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [Homo sapiens]
gi|2462540606|ref|XP_054232211.1|

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