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Inhibition of ATX (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of autotaxin (unknown origin)
Inhibition of human recombinant ATX
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysis
Assay data:4 Active, 5 Activity ≤ 1 µM, 5 Tested
ATX Enzyme Activity Inhibition Assay from US Patent US20230295159: "ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:28 Active, 28 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ENPP2 Assay from US Patent US11591313: "Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof"
Assay data:10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Activity on Human ENPP2 from US Patent US11548883: "Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same"
Assay data:80 Active, 80 Activity ≤ 1 µM, 80 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of LPA-mediated ATX activation in human MDA-MB-231 cells assessed as reduction in cell migration incubated for 4 hrs in using18:1 LPC as substrate by Diff-Quick II staining based method
Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as ERK phosphorylation level incubated for 30 mins by Western blot analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as AKT phosphorylation level incubated for 30 mins by Western blot analysis
Inhibition of ATX stimulated LPA1 internalization in human HeLa-Flp-In cells expressing LPA1-HA assessed as decrease in LPA1 intracellular vesicles under serum starvation condition incubated for 15 mins in presence of 18:1 LPC by confocal imaging analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Negative allosteric modulation activity against human ATX using FS-3 as substrate preincubated for 45 mins followed by substrate addition and measured every 30 mins by multi-mode microplate reader
Assay data:24 Active, 25 Activity ≤ 1 µM, 25 Tested
Inhibition of recombinant human soluble NPP2 expressed in Sf9 insect cells using 1-oleoyl-sn-glycero-3-phosphocholine as substrate measured after 60 mins by TOOS reagent based colorimetric assay
Assay data:1 Tested
Inhibition of human ATX using FS-3 as substrate preincubated for 45 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence based microplate reader analysis
Assay data:31 Active, 1 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Binding affinity to autotaxin (unknown origin) phosphodiesterase activity
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human ATX
Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysis
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Biochemical ATX Assay from US Patent US11465982: "Pyridazines"
Assay data:31 Active, 31 Activity ≤ 1 µM, 31 Tested
Human Autotaxin Assay from US Patent US11344533: "Autotaxin inhibitor compounds"
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Biochemical ATX Assay (Assay A) from US Patent US11104665: "Pyridazines"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
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