BioAssay by Target (List) for Gene (Select 5158) - PubChem BioAssay - NCBI

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Select item 18836871.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Active, 1 Tested

AID:: 1883687

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18725782.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1872578

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18660743.

Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1866074

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18592684.

Inhibition of cAMP-specific 3',5'-cyclic phosphodiesterase (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1859268

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18137415.

Inhibition of human PDE4 at 10 uM relative to control

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1813741

Summary PubMed Citation Related BioAssays by Target

Select item 18121196.

Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1812119

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18068397.

PDE Enzyme Assay from US Patent US11453673: "Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors"

Source:: BindingDB

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:2 Active, 16 Tested

AID:: 1806839

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 18066898.

Enzyme Assays from US Patent US11401274: "[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 7

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1806689

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18061629.

PDE Enzyme Assays Using [3H]cGMP as Substrate from US Patent US11180503: "[1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives"

Source:: BindingDB

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:8 Active, 2 Activity ≤ 1 µM, 13 Tested

AID:: 1806162

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179144110.

PDE6 CEREP ligand profiling

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1791441

Summary Related BioAssays by Target

Select item 177680411.

Inhibition of human PDE6

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Tested

AID:: 1776804

Summary PubMed Citation Related BioAssays by Target

Select item 168535712.

Inhibition of PDE (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1685357

Summary PubMed Citation Related BioAssays by Target

Select item 165941413.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1659414

Summary PubMed Citation Related BioAssays by Target

Select item 163699314.

Inhibition of human PDE

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Active, 1 Tested

AID:: 1636993

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 155232215.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1552322

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 155133716.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:3 Tested

AID:: 1551337

Summary PubMed Citation Related BioAssays by Target

Select item 150858817.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 145891418.

Inhibition of recombinant human PDE6A/PDE6B expressed in insect cells using [3H]cGMP as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by scintillation counting

Source:: ChEMBL

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:2 Tested

AID:: 1458914

Summary PubMed Citation Related BioAssays by Target

Select item 145849619.

Inhibition of recombinant human PDE6A/PDE6B expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:1 Tested

AID:: 1458496

Summary PubMed Citation Related BioAssays by Target

Select item 130680920.

Inhibition of human PDE6AB

Source:: ChEMBL

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:1 Tested

AID:: 1306809

Summary PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (24)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (18)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (37)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (48)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (47)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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