BioAssay by Target (List) for Gene (Select 5137) - PubChem BioAssay - NCBI

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Select item 1589151.

Selectivity ratio for Phosphodiesterase 1 and Phosphodiesterase 5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:2 Tested

AID:: 158915

Summary PubMed Citation Related BioAssays by Target

Select item 2270172.

Relative inhibition of PDE1 (Phosphodiesterase) from human heart and PDE5 from human corpus cavernosum

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:5 Tested

AID:: 227017

Summary PubMed Citation Related BioAssays by Target

Select item 2201753.

Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteries

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:3 Tested

AID:: 220175

Summary PubMed Citation Related BioAssays by Target

Select item 2201744.

Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteries

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Active, 2 Tested

AID:: 220174

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 1590425.

Inhibition of phosphodiesterase Ic isoenzyme

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Assay data:15 Tested

AID:: 159042

Summary PubMed Citation Related BioAssays by Target

Select item 1590416.

Inhibition of Phosphodiesterase (PDE Ic) at 100 uM.

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Assay data:23 Tested

AID:: 159041

Summary PubMed Citation Related BioAssays by Target

Select item 1590407.

Inhibition of phosphodiesterase 1C at 100 uM

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Assay data:1 Tested

AID:: 159040

Summary PubMed Citation Related BioAssays by Target

Select item 1589228.

Inhibition of Phosphodiesterase 1/5 (PDE1/5) from guinea pig trachea (not tested)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:2 Tested

AID:: 158922

Summary PubMed Citation Related BioAssays by Target

Select item 1589219.

Inhibition of phosphodiesterase 1/5 (PDE1/5) from guinea pig tracheal smooth muscle cells (Not determined)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:4 Tested

AID:: 158921

Summary PubMed Citation Related BioAssays by Target

Select item 15892010.

Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [3H]cGMP

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:17 Tested

AID:: 158920

Summary PubMed Citation Related BioAssays by Target

Select item 15891911.

Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea.

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:2 Active, 35 Tested

AID:: 158919

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15891612.

Inhibition of recombinant Phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Tested

AID:: 158916

Summary PubMed Citation Related BioAssays by Target

Select item 22989513.

Selectivity for human heart PDE-1 and human corpus cavernosum PDE-5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:9 Tested

AID:: 229895

Summary PubMed Citation Related BioAssays by Target

Select item 15891414.

Selective inhibition of PDE5 versus PDE1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:7 Tested

AID:: 158914

Summary PubMed Citation Related BioAssays by Target

Select item 15891315.

Inhibition of calcium-calmodulin dependent Phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Active, 3 Tested

AID:: 158913

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15891216.

Inhibition of phosphodiesterase 1 at 200 uM

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:2 Tested

AID:: 158912

Summary PubMed Citation Related BioAssays by Target

Select item 15891117.

Inhibition of phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Tested

AID:: 158911

Summary PubMed Citation Related BioAssays by Target

Select item 15891018.

Inhibitory activity against PDE1 from cerebral cortex

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:18 Tested

AID:: 158910

Summary PubMed Citation Related BioAssays by Target

Select item 15890919.

Inhibition of phosphodiesterase 1 at 20 uM

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Tested

AID:: 158909

Summary PubMed Citation Related BioAssays by Target

Select item 15890820.

Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of sheep lung

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:2 Tested

AID:: 158908

Summary PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (69)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (13)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (54)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (114)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (169)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (169)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (12)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 5137) (182)
PubChem BioAssay
Homo sapiens phosphodiesterase 1C (PDE1C), transcript variant 8, mRNA
Homo sapiens phosphodiesterase 1C (PDE1C), transcript variant 8, mRNA
gi|1890341907|ref|NM_001322057.2|

Nucleotide
UBX domain-containing protein 2B isoform X1 [Chlorocebus sabaeus]
UBX domain-containing protein 2B isoform X1 [Chlorocebus sabaeus]
gi|1938847407|ref|XP_007998892.2|

Protein

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