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Agonist activity at human RXFP3 expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation upto 100 uM measured after 30 mins by TR-FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human RXFP3 expressed in CHO-K1 cells assessed as inhibition of relaxin-3 stimulated ERK1/2 phosphorylation preincubated for 15 mins followed by relaxin-3 addition for 5 mins
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Negative allosteric modulator activity at human RXFP3 expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding at 10 to 30 uM incubated for 1 hr by [35S]GTP-gammaS binding assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Negative allosteric modulator activity at human RXFP3 expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation at 3 to 30 uM measured after 30 mins in presence of relaxin-3 by TR-FRET assay
Antagonist activity at human RXFP3 expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding incubated for 1 hr by [35S]GTP-gammaS binding assay
Assay data:3 Active, 3 Tested
Agonist activity at human RXFP3 expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding incubated for 1 hr by [35S]GTP-gammaS binding assay
Agonist activity at human RXFP3 expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation measured after 30 mins by TR-FRET assay
Antagonist activity at human RXFP3 expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation measured after 30 mins in presence of relaxin-3 by TR-FRET assay
Assay data:18 Active, 1 Activity ≤ 1 µM, 31 Tested
Displacement of [125I]R3/I5 from human RXFP3 expressed in CHO-K1 cells membrane assessed as inhibition constant incubated for 1 hr by microplate scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Displacement of [125I]R3/I5 from human RXFP3 expressed in human CHO-K1 cells incubated for 1 hr by microplate scintillation counting analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as maximal beta arrestin-2 recruitment measured after 4 hrs by beta-galactosidase based beta arrestin2 recruitment assay relative to relaxin 3
Assay data:3 Tested
Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as beta arrestin-2 recruitment measured after 4 hrs by beta-galactosidase based beta arrestin2 recruitment assay
Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as maximal inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs by TR-FRET assay relative to relaxin 3
Assay data:56 Tested
Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs by TR-FRET assay
Assay data:46 Active, 30 Activity ≤ 1 µM, 56 Tested
PRESTO-Tango GPCRome screening (RXFP3)
SummaryRelated BioAssays by Target
Agonist activity at RXFP3 (unknown origin) stably expressed in CHO-K1 cells co-transfected with pCRE assessed as inhibition of forskolin-induced cAMP accumulation measured after 6 hrs by beta-galactosidase reporter gene assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of Eu-labeled H3B1-22R from RXFP3 (unknown origin) stably expressed in CHO-K1 cells by competition binding assay
Agonist activity at human RXFP3 receptor expressed in CHOK1 cells assessed as ERK1/2 phosphorylation incubated for 5 mins by alphascreen surefire assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human RXFP3 receptor expressed in CHOK1 cells cotransfected with beta-galactosidase assessed as inhibition of forskolin-stimulated cAMP by beta-galactosidase reporter gene assay
Assay data:9 Active, 7 Activity ≤ 1 µM, 14 Tested
Displacement of Eu-H3/15 from human RXFP3 receptor expressed in CHOK1 cells by time-resolved fluorescent whole cell binding assay
Assay data:10 Active, 8 Activity ≤ 1 µM, 10 Tested
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