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Panlabs assay PDE11A4
Assay data:1 Tested
SummaryRelated BioAssays by Target
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE11A)
Inhibition of human recombinant PDE11
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PDE11
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (PDE panel (enzymatic activity assay)) EUB0000751a PDE11A
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (PDE panel (enzymatic assay)) EUB0000744a PDE11A
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of full length human PDE11A using [3H]-cAMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis
Inhibition of PDE11A4 (588 to 911 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting method
Assay data:2 Tested
Inhibtion Assay from US Patent US9493447: "Optically active PDE10 inhibitor"
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Fluorescence Polarization Assay from US Patent US9388139: "Derivatives of celeboxib, use thereof and preparation thereof"
Assay data:26 Active, 28 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Caliper Mobility-Shift Assay from US Patent US9359371: "Bicyclic substituted pyrimidine compounds"
Assay data:15 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Enzyme Assay from US Patent US9173884: "Inhibitors of phosphodiesterase 11 (PDE11)"
Assay data:21 Active, 13 Activity ≤ 1 µM, 25 Tested
Inhibition Assay from US Patent US9067945: "Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes"
In Vitro Enzyme Assay from Article 10.1016/j.chembiol.2011.12.010: "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen."
Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested
Phosphodiesterase (PDE) Inhibition Assay from Article 10.1016/j.str.2004.10.004: "Structural basis for the activity of drugs that inhibit phosphodiesterases."
Assay data:10 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
PDE11 (h) CEREP ligand profiling
Biochemical assay (PDE11A)
Assay data:1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
hPDE11A4 PDE scan
Inhibition of PDE11A4 (unknown origin) at 10 uM relative to control
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
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