BioAssay by Target (List) for Gene (Select 50940) - PubChem BioAssay - NCBI

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Select item 19624811.

Panlabs assay PDE11A4

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1962481

Summary Related BioAssays by Target

Select item 19624642.

3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE11A)

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1962464

Summary Related BioAssays by Target

Select item 19244963.

Inhibition of human recombinant PDE11

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 1924496

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19244514.

Inhibition of human PDE11

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1924451

Summary PubMed Citation Related BioAssays by Target

Select item 19146655.

Selectivity interaction (PDE panel (enzymatic activity assay)) EUB0000751a PDE11A

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914665

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19146136.

Selectivity interaction (PDE panel (enzymatic assay)) EUB0000744a PDE11A

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Active, 1 Tested

AID:: 1914613

Summary Compounds, Active Related BioAssays by Target

Select item 18979197.

Inhibition of full length human PDE11A using [3H]-cAMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1897919

Summary PubMed Citation Related BioAssays by Target

Select item 18120848.

Inhibition of PDE11A4 (588 to 911 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting method

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:2 Tested

AID:: 1812084

Summary PubMed Citation Related BioAssays by Target

Select item 18035329.

Inhibtion Assay from US Patent US9493447: "Optically active PDE10 inhibitor"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 11

Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1803532

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180309810.

Fluorescence Polarization Assay from US Patent US9388139: "Derivatives of celeboxib, use thereof and preparation thereof"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 8

Assay data:26 Active, 28 Tested

AID:: 1803098

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 180304911.

Caliper Mobility-Shift Assay from US Patent US9359371: "Bicyclic substituted pyrimidine compounds"

Source:: BindingDB

Protein Targets:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; ...
Total:: 1

Assay data:15 Tested

AID:: 1803049

Summary Related BioAssays by Depositor Related BioAssays by Target

Select item 180180012.

In Vitro Enzyme Assay from US Patent US9173884: "Inhibitors of phosphodiesterase 11 (PDE11)"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; ...
Total:: 11

Assay data:21 Active, 13 Activity ≤ 1 µM, 25 Tested

AID:: 1801800

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180137413.

Inhibition Assay from US Patent US9067945: "Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; ...
Total:: 10

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1801374

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179970614.

In Vitro Enzyme Assay from Article 10.1016/j.chembiol.2011.12.010: "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen."

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; ...
Total:: 10

Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested

AID:: 1799706

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 179729615.

Phosphodiesterase (PDE) Inhibition Assay from Article 10.1016/j.str.2004.10.004: "Structural basis for the activity of drugs that inhibit phosphodiesterases."

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; ...
Total:: 10

Assay data:10 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested

AID:: 1797296

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 179143616.

PDE11 (h) CEREP ligand profiling

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1791436

Summary Related BioAssays by Target

Select item 179123317.

Biochemical assay (PDE11A)

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Activity ≤ 1 µM, 2 Tested

AID:: 1791233

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 178701518.

hPDE11A4 PDE scan

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1787015

Summary Related BioAssays by Target

Select item 178304119.

Inhibition of PDE11A4 (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:1 Tested

AID:: 1783041

Summary PubMed Citation Related BioAssays by Target

Select item 177680920.

Inhibition of human PDE11

Source:: ChEMBL

Protein Target:: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1776809

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (47)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (38)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (87)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (120)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (113)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (19)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 50940) (133)
PubChem BioAssay
Homo sapiens isolate:CHM13
Homo sapiens isolate:CHM13
Homo sapiens isolate:CHM13 RefSeq Genome sequencing and assembly

BioProject
BioProject Links for Nucleotide (Select 2462590925) (1)
BioProject
RefSeq Protein Links for Gene (Select 50940) (4)
Protein
Homo sapiens EP300 interacting inhibitor of differentiation 3 (EID3), mRNA
Homo sapiens EP300 interacting inhibitor of differentiation 3 (EID3), mRNA
gi|1653961144|ref|NM_001008394.3|

Nucleotide

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