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Antagonist activity at P2Y1R (unknown origin) expressed in human 1321N1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 15 mins in presence of IBMX by chromatography
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human P2Y1R expressed in HEK293 cells assessed as inhibition of ADP-induced IP3 production preincubated for 0.5 hrs followed by ADP stimulation by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at P2Y1 receptor (unknown origin)
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Binding affinity to P2Y1 receptor (unknown origin)
Displacement of [3H]2MeSADP from human P2Y1 expressed in U2OS cell membranes incubated for 60 mins by scintillation counting method
Scintillation Proximity Assay (SPA) from US Patent US9428504: "7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor"
Assay data:156 Active, 156 Activity ≤ 1 µM, 156 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay from US Patent US9428504: "7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor"
Assay data:13 Active, 12 Activity ≤ 1 µM, 13 Tested
Binding Assay from US Patent US9120798: "Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Scintillation Proximity Assay (SPA) Assay from US Patent US9120798: "Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor"
Assay data:40 Active, 40 Activity ≤ 1 µM, 40 Tested
Scintillation Proximity Assay (SPA) from US Patent US9540323: "7-hydroxy-indolinyl antagonists of P2Y1 receptor"
Assay data:267 Active, 267 Activity ≤ 1 µM, 267 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PRESTO-Tango GPCRome screening (P2RY1)
SummaryRelated BioAssays by Target
P2Y CEREP ligand profiling
P2Y-purinergic receptor CEREP ligand profiling
P2Y Ligand binding assay
Antagonist activity at human P2Y1 receptor expressed in human 1321N1 cells assessed as inhibition of ADP-induced intracellular calcium influx at 10 uM preincubated for 20 mins followed by ADP addition measured at 0.4 secs interval for 60 times by Oregon Green BAPTA-1/AM dye-based fluorescence assay
Assay data:36 Tested
Antagonist activity against human P2Y1 in human 1321N1 cells assessed as effect on calcium transients
Agonist activity at human P2Y1 in human 1321N1 cells assessed as effect on calcium transients
Antagonist activity at human P2Y1R expressed in human 1321N1 cells assessed as inhibition of 2-MeSADP-mediated calcium mobilization at 10 uM by PDSP assay
Assay data:3 Tested
Agonist activity at human P2Y1R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM after 1 hr by FLIPR assay
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